<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01873834</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T02:23:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Combined HAT/EZH2 modulation leads to cancer-selective cell death</title>
            <author role="aut">
              <persName>
                <forename type="first">Francesca</forename>
                <surname>Petraglia</surname>
              </persName>
              <idno type="halauthorid">1422155-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Abhishek</forename>
                <surname>Singh</surname>
              </persName>
              <idno type="halauthorid">673093-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincenzo</forename>
                <surname>Carafa</surname>
              </persName>
              <idno type="halauthorid">383934-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Angela</forename>
                <surname>Nebbioso</surname>
              </persName>
              <idno type="halauthorid">240599-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mariarosaria</forename>
                <surname>Conte</surname>
              </persName>
              <idno type="halauthorid">383932-0</idno>
              <affiliation ref="#struct-511526"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lucia</forename>
                <surname>Scisciola</surname>
              </persName>
              <idno type="halauthorid">1422157-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sergio</forename>
                <surname>Valente</surname>
              </persName>
              <idno type="halauthorid">372818-0</idno>
              <affiliation ref="#struct-229915"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alfonso</forename>
                <surname>Baldi</surname>
              </persName>
              <email type="md5">f093816f6b840875f0f744e799435e87</email>
              <email type="domain">tiscali.it</email>
              <idno type="idhal" notation="numeric">911290</idno>
              <idno type="halauthorid" notation="string">418030-911290</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amit</forename>
                <surname>Mandoli</surname>
              </persName>
              <idno type="halauthorid">1422156-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valeria</forename>
                <surname>Petrizzi</surname>
              </persName>
              <idno type="halauthorid">1422206-0</idno>
              <affiliation ref="#struct-334562"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Concetta</forename>
                <surname>Ingenito</surname>
              </persName>
              <idno type="halauthorid">1422207-0</idno>
              <affiliation ref="#struct-334562"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandro</forename>
                <surname>de Falco</surname>
              </persName>
              <idno type="halauthorid">1422208-0</idno>
              <affiliation ref="#struct-112685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valeria</forename>
                <surname>Cicatiello</surname>
              </persName>
              <idno type="halauthorid">1422209-0</idno>
              <affiliation ref="#struct-112685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ivana</forename>
                <surname>Apicella</surname>
              </persName>
              <idno type="halauthorid">1422210-0</idno>
              <affiliation ref="#struct-112685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eva</forename>
                <surname>Janssen-Megens</surname>
              </persName>
              <idno type="halauthorid">1422158-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bowon</forename>
                <surname>Kim</surname>
              </persName>
              <idno type="halauthorid">1422159-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guoqiang</forename>
                <surname>Yi</surname>
              </persName>
              <idno type="halauthorid">1042928-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Colin</forename>
                <surname>Logie</surname>
              </persName>
              <idno type="halauthorid">1249036-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Simon</forename>
                <surname>Heath</surname>
              </persName>
              <idno type="halauthorid">197478-0</idno>
              <affiliation ref="#struct-435231"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Menotti</forename>
                <surname>Ruvo</surname>
              </persName>
              <idno type="halauthorid">459747-0</idno>
              <affiliation ref="#struct-120624"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Albertus</forename>
                <surname>Wierenga</surname>
              </persName>
              <idno type="halauthorid">1422160-0</idno>
              <affiliation ref="#struct-162742"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Flicek</surname>
              </persName>
              <email type="md5">f1b332c3488a66cb322ea43c21751ecd</email>
              <email type="domain">ebi.ac.uk</email>
              <idno type="idhal" notation="numeric">919968</idno>
              <idno type="halauthorid" notation="string">615292-919968</idno>
              <affiliation ref="#struct-182329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie Laure</forename>
                <surname>Yaspo</surname>
              </persName>
              <idno type="halauthorid">1422162-0</idno>
              <affiliation ref="#struct-337076"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Véronique</forename>
                <surname>Della Valle</surname>
              </persName>
              <idno type="halauthorid">1061129-0</idno>
              <affiliation ref="#struct-456973"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Bernard</surname>
              </persName>
              <idno type="halauthorid">43218-0</idno>
              <orgName ref="#struct-456973"/>
              <affiliation ref="#struct-456973"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stefano</forename>
                <surname>Tomassi</surname>
              </persName>
              <idno type="halauthorid">816698-0</idno>
              <affiliation ref="#struct-251386"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ettore</forename>
                <surname>Novellino</surname>
              </persName>
              <idno type="idhal" notation="numeric">770857</idno>
              <idno type="halauthorid" notation="string">806236-770857</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2181-2142</idno>
              <affiliation ref="#struct-544964"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alessandra</forename>
                <surname>Feoli</surname>
              </persName>
              <idno type="halauthorid">1422211-0</idno>
              <affiliation ref="#struct-302831"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gianluca</forename>
                <surname>Sbardella</surname>
              </persName>
              <idno type="halauthorid">816667-0</idno>
              <affiliation ref="#struct-302831"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ivo</forename>
                <surname>Gut</surname>
              </persName>
              <idno type="halauthorid">345171-0</idno>
              <affiliation ref="#struct-182218"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edo</forename>
                <surname>Vellenga</surname>
              </persName>
              <idno type="halauthorid">455667-0</idno>
              <affiliation ref="#struct-162742"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hendrik</forename>
                <forename type="middle">G.</forename>
                <surname>Stunnenberg</surname>
              </persName>
              <idno type="halauthorid">339122-0</idno>
              <affiliation ref="#struct-300856"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Antonello</forename>
                <surname>Mai</surname>
              </persName>
              <idno type="halauthorid">372819-0</idno>
              <affiliation ref="#struct-251386"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Joost</forename>
                <surname>Martens</surname>
              </persName>
              <idno type="halauthorid">1422163-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lucia</forename>
                <surname>Altucci</surname>
              </persName>
              <idno type="halauthorid">240597-0</idno>
              <affiliation ref="#struct-524781"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Amel</forename>
                <surname>BOUAKAZ</surname>
              </persName>
              <email type="md5">c2cc773286f84e5df8853d162ec9383b</email>
              <email type="domain">calym.org</email>
            </editor>
            <funder>This work was supported by BLUEPRINT (282510), Programma VALERE: Vanvitelli per la Ricerca; the Italian-Flag Project-EPIGEN, PRIN-20152TE5PK, the Italian association against cancer (AIRC-17217), the Dutch Cancer Foundation (KWF kun 2011–4937) and Netherlands organization for Scientific Research (NWO-VIDI).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-09-17 15:20:48</date>
              <date type="whenModified">2026-03-10 10:02:02</date>
              <date type="whenReleased">2018-10-08 08:08:03</date>
              <date type="whenProduced">2018-05-22</date>
              <date type="whenEndEmbargoed">2018-09-17</date>
              <ref type="file" target="https://hal.science/hal-01873834v1/document">
                <date notBefore="2018-09-17"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-01873834v1/file/25428-1004878-5-PB.pdf" id="file-1875587-1903399">
                <date notBefore="2018-09-17"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986654"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="484770">
                <persName>
                  <forename>Amel</forename>
                  <surname>BOUAKAZ</surname>
                </persName>
                <email type="md5">c2cc773286f84e5df8853d162ec9383b</email>
                <email type="domain">calym.org</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01873834</idno>
            <idno type="halUri">https://hal.science/hal-01873834</idno>
            <idno type="halBibtex">petraglia:hal-01873834</idno>
            <idno type="halRefHtml">&lt;i&gt;Oncotarget&lt;/i&gt;, 2018, 9 (39), pp.25630-25646. &lt;a target="_blank" href="https://dx.doi.org/10.18632/oncotarget.25428"&gt;&amp;#x27E8;10.18632/oncotarget.25428&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Oncotarget, 2018, 9 (39), pp.25630-25646. &amp;#x27E8;10.18632/oncotarget.25428&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-1875587-1903399"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="UNIV-PSUD">Université Paris Sud - Paris XI</idno>
            <idno type="stamp" n="RIIP_FCB" corresp="RIIP">Institut Pasteur - Fondation Cenci Bolognetti</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="INSERM-SACLAY" corresp="UNIV-PARIS-SACLAY">INSERM-SACLAY</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="CALYM">Institut Carnot CALYM</idno>
            <idno type="stamp" n="UNIV-PSUD-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris Sud pour Paris Saclay</idno>
            <idno type="stamp" n="IGR-SACLAY" corresp="UNIV-PARIS-SACLAY">IGR-SACLAY</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="DYNAMO">Dynamique moléculaire de la transformation hématopoïétique </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Combined HAT/EZH2 modulation leads to cancer-selective cell death</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Francesca</forename>
                    <surname>Petraglia</surname>
                  </persName>
                  <idno type="halauthorid">1422155-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Abhishek</forename>
                    <surname>Singh</surname>
                  </persName>
                  <idno type="halauthorid">673093-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincenzo</forename>
                    <surname>Carafa</surname>
                  </persName>
                  <idno type="halauthorid">383934-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angela</forename>
                    <surname>Nebbioso</surname>
                  </persName>
                  <idno type="halauthorid">240599-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mariarosaria</forename>
                    <surname>Conte</surname>
                  </persName>
                  <idno type="halauthorid">383932-0</idno>
                  <affiliation ref="#struct-511526"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucia</forename>
                    <surname>Scisciola</surname>
                  </persName>
                  <idno type="halauthorid">1422157-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sergio</forename>
                    <surname>Valente</surname>
                  </persName>
                  <idno type="halauthorid">372818-0</idno>
                  <affiliation ref="#struct-229915"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alfonso</forename>
                    <surname>Baldi</surname>
                  </persName>
                  <email type="md5">f093816f6b840875f0f744e799435e87</email>
                  <email type="domain">tiscali.it</email>
                  <idno type="idhal" notation="numeric">911290</idno>
                  <idno type="halauthorid" notation="string">418030-911290</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amit</forename>
                    <surname>Mandoli</surname>
                  </persName>
                  <idno type="halauthorid">1422156-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valeria</forename>
                    <surname>Petrizzi</surname>
                  </persName>
                  <idno type="halauthorid">1422206-0</idno>
                  <affiliation ref="#struct-334562"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Concetta</forename>
                    <surname>Ingenito</surname>
                  </persName>
                  <idno type="halauthorid">1422207-0</idno>
                  <affiliation ref="#struct-334562"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandro</forename>
                    <surname>de Falco</surname>
                  </persName>
                  <idno type="halauthorid">1422208-0</idno>
                  <affiliation ref="#struct-112685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valeria</forename>
                    <surname>Cicatiello</surname>
                  </persName>
                  <idno type="halauthorid">1422209-0</idno>
                  <affiliation ref="#struct-112685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ivana</forename>
                    <surname>Apicella</surname>
                  </persName>
                  <idno type="halauthorid">1422210-0</idno>
                  <affiliation ref="#struct-112685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eva</forename>
                    <surname>Janssen-Megens</surname>
                  </persName>
                  <idno type="halauthorid">1422158-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bowon</forename>
                    <surname>Kim</surname>
                  </persName>
                  <idno type="halauthorid">1422159-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guoqiang</forename>
                    <surname>Yi</surname>
                  </persName>
                  <idno type="halauthorid">1042928-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Colin</forename>
                    <surname>Logie</surname>
                  </persName>
                  <idno type="halauthorid">1249036-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Simon</forename>
                    <surname>Heath</surname>
                  </persName>
                  <idno type="halauthorid">197478-0</idno>
                  <affiliation ref="#struct-435231"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Menotti</forename>
                    <surname>Ruvo</surname>
                  </persName>
                  <idno type="halauthorid">459747-0</idno>
                  <affiliation ref="#struct-120624"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Albertus</forename>
                    <surname>Wierenga</surname>
                  </persName>
                  <idno type="halauthorid">1422160-0</idno>
                  <affiliation ref="#struct-162742"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Flicek</surname>
                  </persName>
                  <email type="md5">f1b332c3488a66cb322ea43c21751ecd</email>
                  <email type="domain">ebi.ac.uk</email>
                  <idno type="idhal" notation="numeric">919968</idno>
                  <idno type="halauthorid" notation="string">615292-919968</idno>
                  <affiliation ref="#struct-182329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie Laure</forename>
                    <surname>Yaspo</surname>
                  </persName>
                  <idno type="halauthorid">1422162-0</idno>
                  <affiliation ref="#struct-337076"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Véronique</forename>
                    <surname>Della Valle</surname>
                  </persName>
                  <idno type="halauthorid">1061129-0</idno>
                  <affiliation ref="#struct-456973"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Bernard</surname>
                  </persName>
                  <idno type="halauthorid">43218-0</idno>
                  <orgName ref="#struct-456973"/>
                  <affiliation ref="#struct-456973"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stefano</forename>
                    <surname>Tomassi</surname>
                  </persName>
                  <idno type="halauthorid">816698-0</idno>
                  <affiliation ref="#struct-251386"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ettore</forename>
                    <surname>Novellino</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">770857</idno>
                  <idno type="halauthorid" notation="string">806236-770857</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2181-2142</idno>
                  <affiliation ref="#struct-544964"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alessandra</forename>
                    <surname>Feoli</surname>
                  </persName>
                  <idno type="halauthorid">1422211-0</idno>
                  <affiliation ref="#struct-302831"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gianluca</forename>
                    <surname>Sbardella</surname>
                  </persName>
                  <idno type="halauthorid">816667-0</idno>
                  <affiliation ref="#struct-302831"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ivo</forename>
                    <surname>Gut</surname>
                  </persName>
                  <idno type="halauthorid">345171-0</idno>
                  <affiliation ref="#struct-182218"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edo</forename>
                    <surname>Vellenga</surname>
                  </persName>
                  <idno type="halauthorid">455667-0</idno>
                  <affiliation ref="#struct-162742"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hendrik</forename>
                    <forename type="middle">G.</forename>
                    <surname>Stunnenberg</surname>
                  </persName>
                  <idno type="halauthorid">339122-0</idno>
                  <affiliation ref="#struct-300856"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Antonello</forename>
                    <surname>Mai</surname>
                  </persName>
                  <idno type="halauthorid">372819-0</idno>
                  <affiliation ref="#struct-251386"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Joost</forename>
                    <surname>Martens</surname>
                  </persName>
                  <idno type="halauthorid">1422163-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucia</forename>
                    <surname>Altucci</surname>
                  </persName>
                  <idno type="halauthorid">240597-0</idno>
                  <affiliation ref="#struct-524781"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">102112</idno>
                <idno type="issn">1949-2553</idno>
                <title level="j">Oncotarget</title>
                <imprint>
                  <publisher>Impact journals</publisher>
                  <biblScope unit="volume">9</biblScope>
                  <biblScope unit="issue">39</biblScope>
                  <biblScope unit="pp">25630-25646</biblScope>
                  <date type="datePub">2018-05-22</date>
                </imprint>
              </monogr>
              <idno type="doi">10.18632/oncotarget.25428</idno>
              <idno type="pubmed">29876013</idno>
              <idno type="pubmedcentral">PMC5986654</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">cancer</term>
                <term xml:lang="en">apoptosis</term>
                <term xml:lang="en">acetylation</term>
                <term xml:lang="en">epigenetics</term>
                <term xml:lang="en">methylation</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Epigenetic alterations have been associated with both pathogenesis and progression of cancer. By screening of library compounds, we identified a novel hybrid epi-drug MC2884, a HAT/EZH2 inhibitor, able to induce bona fide cancer-selective cell death in both solid and hematological cancers in vitro, ex vivo and in vivo xenograft models. Anticancer action was due to an epigenome modulation by H3K27me3, H3K27ac, H3K9/14ac decrease, and to caspase-dependent apoptosis induction. MC2884 triggered mitochondrial pathway apoptosis by up-regulation of cleaved-BID, and strong down-regulation of BCL2. Even aggressive models of cancer, such as p53-/- or TET2-/- cells, responded to MC2884, suggesting MC2884 therapeutic potential also for the therapy of TP53 or TET2-deficient human cancers. MC2884 induced massive apoptosis in ex vivo human primary leukemia blasts with poor prognosis in vivo, by targeting BCL2 expression. MC2884-treatment reduced acetylation of the BCL2 promoter at higher level than combined p300 and EZH2 inhibition. This suggests a key role for BCL-2 reduction in potentiating responsiveness, also in combination therapy with BCL2 inhibitors. Finally, we identified both the mechanism of MC2884 action as well as a potential therapeutic scheme of its use. Altogether, this provides proof of concept for the use of epi-drugs coupled with epigenome analyses to 'personalize' precision medicine.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-524781" status="VALID">
          <orgName>Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli</orgName>
          <desc>
            <address>
              <addrLine>Viale Abramo Lincoln n. 5 - 81100 Caserta</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unina2.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300856" status="VALID">
          <idno type="IdRef">112681611</idno>
          <idno type="ROR">https://ror.org/016xsfp80</idno>
          <orgName>Radboud University [Nijmegen]</orgName>
          <desc>
            <address>
              <addrLine>Houtlaan 4, 6525 XZ Nijmegen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.ru.nl/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-511526" status="VALID">
          <orgName>Institut de Recherche Vétérinaire de Tunisie = Veterinary Research Institute of Tunis</orgName>
          <orgName type="acronym">IRVT</orgName>
          <desc>
            <address>
              <addrLine>20 Rue Djebel Lakhdar – La Rabta 1006 – Tunis</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">http://www.irvt.agrinet.tn/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-229915" status="VALID">
          <idno type="IdRef">026430711</idno>
          <idno type="ROR">https://ror.org/02be6w209</idno>
          <orgName>Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]</orgName>
          <orgName type="acronym">UNIROMA</orgName>
          <date type="start">1303-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro 5, 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.uniroma1.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-334562" status="INCOMING">
          <orgName>Ospedale Umberto I</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-112685" status="VALID">
          <orgName>Istituto di Genetica e Biofisica “Adriano Buzzati Traverso”/ Institute of Genetics and Biophysics  [Naples, Italie]</orgName>
          <orgName type="acronym">IGB-CNR</orgName>
          <desc>
            <address>
              <addrLine>Via Pietro Castellino 111, 80131 Naples</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">http://www.igb.cnr.it/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-254021" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-435231" status="VALID">
          <idno type="ROR">https://ror.org/03mynna02</idno>
          <orgName>Centro Nacional de Analisis Genomico [Barcelona]</orgName>
          <orgName type="acronym">CNAG</orgName>
          <desc>
            <address>
              <addrLine>Baldiri Reixac, 4Barcelona Science Park - Tower I08028 Barcelona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.cnag.cat/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-120624" status="INCOMING">
          <orgName>CNR – Istituto di Biostrutture e Bioimmagini</orgName>
          <desc>
            <address>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-329308" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-162742" status="VALID">
          <idno type="ROR">https://ror.org/03cv38k47</idno>
          <orgName>University Medical Center Groningen [Groningen]</orgName>
          <orgName type="acronym">UMCG</orgName>
          <desc>
            <address>
              <addrLine>PO box 30.0019700 RB Groningen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.umcg.nl/EN/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-182329" status="VALID">
          <orgName>European Bioinformatics Institute [Hinxton]</orgName>
          <orgName type="acronym">EMBL-EBI</orgName>
          <desc>
            <address>
              <addrLine>EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.ebi.ac.uk/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-307014" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-337076" status="VALID">
          <orgName>Max Planck Institute for Molecular Genetics</orgName>
          <orgName type="acronym">MPIMG</orgName>
          <desc>
            <address>
              <addrLine>Ihnestraße 63-73, 14195 Berlin</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.molgen.mpg.de/2168/en</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5247" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-456973" status="OLD">
          <orgName>Hématopoïèse normale et pathologique</orgName>
          <orgName type="acronym">U1170 Inserm</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Gustave Roussy - Pavillon de recherche 1 - 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-92966" type="direct"/>
            <relation active="#struct-156104" type="direct"/>
            <relation name="U1170" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-251386" status="VALID">
          <orgName>Department of Medicinal Chemistry and Technologies</orgName>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro 5, I-00185, Rome</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-55932" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation active="#struct-229915" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-544964" status="VALID">
          <idno type="IdRef">026430622</idno>
          <idno type="ROR">https://ror.org/05290cv24</idno>
          <orgName>University of Naples Federico II = Università degli studi di Napoli Federico II</orgName>
          <orgName type="acronym">UNINA</orgName>
          <desc>
            <address>
              <addrLine>Via Cintia Monte S. Angelo, 80126 Napoli, Italy</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unina.it</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302831" status="VALID">
          <idno type="ISNI">0000000419370335</idno>
          <idno type="ROR">https://ror.org/0192m2k53</idno>
          <orgName>Università degli Studi di Salerno = University of Salerno</orgName>
          <orgName type="acronym">UNISA</orgName>
          <desc>
            <address>
              <addrLine>Via Giovanni Paolo II, 132 - 84084 Fisciano (SA)</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unisa.it/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-182218" status="VALID">
          <orgName>Centro Nacional de Análisi Genómico</orgName>
          <orgName type="acronym">CNAG</orgName>
          <desc>
            <address>
              <addrLine>Generalitat de Catalunya - Departament de SalutGeneralitat de Catalunya - Departament d'InnovacióMinisterio de Ciendia e InnovaciónParc Científic de Barcelona baldiri reixac, 4 pcb - tower i 08028 Barcelona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.cnag.cat/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-435231" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-254021" status="VALID">
          <idno type="ISNI">0000 0001 2159 6200</idno>
          <idno type="ROR">https://ror.org/04zaypm56</idno>
          <orgName>National Research Council of Italy | Consiglio Nazionale delle Ricerche</orgName>
          <orgName type="acronym">CNR</orgName>
          <date type="start">1923-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro, 7 - 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.cnr.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-329308" status="INCOMING">
          <orgName>CNR – Istituto di Biostrutture e Bioimmagini</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-307014" status="VALID">
          <orgName>EMBL Heidelberg</orgName>
          <desc>
            <address>
              <addrLine>Meyerhofstraße 1 69117 Heidelberg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.embl.de/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-5247" status="VALID">
          <orgName>Max-Planck-Gesellschaft</orgName>
          <desc>
            <address>
              <addrLine>Jägerstrasse, 10-11, D-10117 Berlin</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.mpg.de/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92966" status="OLD">
          <idno type="ROR">https://ror.org/028rypz17</idno>
          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-55932" status="VALID">
          <idno type="ROR">https://ror.org/051v7w268</idno>
          <orgName>Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti</orgName>
          <date type="start">1964-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rome La Sapienza 5 Place Aldo Moro 00185 Rome</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">http://www.istitutopasteuritalia.it/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>