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                <term xml:lang="en">risk factors</term>
                <term xml:lang="en">vector-borne infections</term>
                <term xml:lang="en">viruses</term>
                <term xml:lang="en">epidemiology</term>
                <term xml:lang="en">dengue virus</term>
                <term xml:lang="en">dengue</term>
                <term xml:lang="en">asymptomatic</term>
                <term xml:lang="en">Mekong</term>
                <term xml:lang="en">Cambodia</term>
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                <term xml:lang="en">Aedes albopictus</term>
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              <p>We investigated dengue virus (DENV) and asymptomatic DENV infections in rural villages of Kampong Cham Province, Cambodia, during 2012 and 2013. We conducted perifocal investigations in and around households for 149 DENV index cases identified through hospital and village surveillance. We tested participants 0.5–30 years of age by using nonstructural 1 rapid tests and confirmed DENV infections using quantitative reverse transcription PCR or nonstructural 1–capture ELISA. We used multivariable Poisson regressions to explore links between participants’ DENV infection status and household characteristics. Of 7,960 study participants, 346 (4.4%) were infected with DENV, among whom 302 (87.3%) were &lt;15 years of age and 225 (65.0%) were &lt;9 years of age. We identified 26 (7.5%) participants with strictly asymptomatic DENV infection at diagnosis and during follow-up. We linked symptomatic DENV infection status to familial relationships with index cases. During the 2-year study, we saw fewer asymptomatic DENV infections than expected based on the literature.</p>
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              <org type="consortium">The authors gratefully acknowledge participating hospitals, villages, and study participants, as well as Tineke Cantaert for her editorial comments and suggestion</org>
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            <address>
              <addrLine>Kampong Cham</addrLine>
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            </address>
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            <ref type="url">https://pasteur-network.org/</ref>
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          <orgName type="acronym">UC</orgName>
          <date type="start">1869-01-01</date>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">https://www.universityofcalifornia.edu/</ref>
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        <org type="europeanProject" xml:id="projeurop-86019" status="VALID">
          <idno type="number">282378</idno>
          <idno type="program">FP7-HEALTH-2011-single-stage</idno>
          <idno type="call">FP7-HEALTH-2011-single-stage</idno>
          <orgName>DENFREE</orgName>
          <desc>Dengue research Framework for Resisting Epidemics in Europe</desc>
          <date type="start">2012-01-01</date>
          <date type="end">2016-12-31</date>
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