An intrinsically disordered region in MED13 turns Mediator on/off on cue
Résumé
Complementary studies by Zhao et al. 1 and Chen et al. 2 reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching on and off Mediator and transcription activation.