%0 Journal Article %T Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal. %+ Institut Pasteur de Dakar %+ Hôpital Aristide-Le-Dantec %A Seck, Abdoulaye %A Mbengue, Mouhamadou %A Gassama-Sow, Amy %A Diouf, Lamine %A Ka, Mouhamadou Mourtalla %A Boye, Cheikh Saad-Bouh %Z This work was financed from own funds by the Service de Gastro-entérologie and the Laboratoire de Bactériologie-virologie, Hôpital Arsitide Le Dantec, Dakar Sénégal. This work was carried out in the Laboratoire de Bactériologie-virologie, Hôpital Arsitide Le Dantec, Dakar Sénégal %< avec comité de lecture %@ 2036-6590 %J Journal of Infection in Developing Countries %I Independent %V 3 %N 2 %P 137-140 %8 2009 %D 2009 %R 10.3855/jidc.512 %M 19755744 %K Helicobacter pylori %K antimicrobial susceptibility %K Senegal %Z Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyJournal articles %X Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics.Methodology: H. pylori isolates from gastric biopsies from outpatients ≥ 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method.Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs ≥ 8 µg/l), whereas all isolates were susceptible to amoxicillin (MICs ≤ 0. 5 µg/ml) and ciprofloxacin (MICs ≤ 1µg/ml).Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal. %G English %Z We thank Ibrahima Bahsoun and Alfred Dieudonne Kinana for critical reading of the manuscript %2 https://riip.hal.science/pasteur-00584222/document %2 https://riip.hal.science/pasteur-00584222/file/512-1093-1-PB.pdf %L pasteur-00584222 %U https://riip.hal.science/pasteur-00584222 %~ RIIP %~ RIIP_DAKAR