%0 Journal Article %T Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells. %+ Key Laboratory of Molecular Virology & Immunology (LMVI) %+ Department of Surgery %+ School of Life Sciences [Fudan University] %A Gao, Y. %A Lin, F. %A Su, J. %A Gao, Z. %A Li, Y. %A Yang, J. %A Deng, Z. %A Liu, B. %A Tsun, A. %A Li, B. %Z The research is supported by the National Science Foundation of China (NSFC) 30972702, SMCST09JC1416100; Shanghai Pasteur Foundation; Shanghai 'Rising Star' program 10QA1407900; China-Germany PPP program; Novo Nordisk-Chinese Academy of Sciences Foundation; and the Chinese Academy of Sciences (CAS) network lab program. BL is a recipient of CAS '100-talent' program. AT is a recipient of CAS 'International Young Scientist Fellowship' and supported by NSFC 31050110129. We gratefully acknowledge the support of the Sanofi-Aventis-Shanghai Institutes for Biological Sciences scholarship program. %< avec comité de lecture %@ 1466-4879 %J Genes and Immunity %I Nature Publishing Group: Open Access Hybrid Model Option B %V 13 %N 1 %P 1-13 %8 2012-01 %D 2012 %R 10.1038/gene.2011.77 %M 22048454 %Z Life Sciences [q-bio]/ImmunologyJournal articles %X CD4(+) CD25(+) regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance and homeostasis by limiting aberrant or excessive inflammation. The transcription factor forkhead box P3 (FOXP3) is critical for the development and function of Treg cells. The differentiation of the Treg cell lineage is not terminal, as developmental and functional plasticity occur through the sensing of inflammatory signals in the periphery. Here, we review the recent progress in our understanding of the molecular mechanisms underlying the regulation and functional plasticity of CD4(+) CD25(+) FOXP3(+) Treg cells, through the perturbation of FOXP3 and its complex at a transcriptional, translational and post-translational level. %G English %L pasteur-00723687 %U https://riip.hal.science/pasteur-00723687 %~ RIIP