%0 Journal Article %T Spectrum of disease among HIV-infected adults hospitalised in a respiratory medicine unit in Abidjan, Côte d'Ivoire. %+ Projet RETRO-CI %+ London School of Hygiene and Tropical Medicine (LSHTM) %+ Service de Pneumophtisiologie %+ Centre de Diagnostic et de Recherche sur le SIDA %+ Institut Pasteur de Côte d'Ivoire %+ Division of HIV/AIDS Prevention %+ Department of Histopathology %A Grant, A. D. %A Sidibé, K. %A Domoua, K. %A Bonard, D. %A Sylla-Koko, F. %A Dosso, M. %A Yapi, A. %A Maurice, C. %A Whitaker, J. P. %A Lucas, S. B. %A Hayes, R. J. %A Wiktor, S. Z. %A de Cock, K. M. %A Greenberg, A. E. %Z Funding was also received from the Roche African Research Foundation and the Rockefeller Foundation. %< avec comité de lecture %@ 1027-3719 %J International Journal of Tuberculosis and Lung Disease %I International Union Against Tuberculosis and Lung Disease %V 2 %N 11 %P 926-34 %8 1998-11 %D 1998 %M 9848615 %K HIV-1 %K HIV-2 %K Africa %K tuberculosis %K AIDS- related opportunistic infections %K CD4 lymphocyte count %Z Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyJournal articles %X SETTING: Respiratory medicine wards of the University Teaching Hospital, Abidjan, Côte d'Ivoire. OBJECTIVES: To describe the spectrum of opportunistic infection among human immunodeficiency virus (HIV) infected adults hospitalised in the respiratory medicine unit in Abidjan, and the level of immunosuppression at which these diseases occur. DESIGN: Cross-sectional study. RESULTS: Overall, 75% of patients were HIV-positive: among these patients, the most frequent diagnosis was tuberculosis, in 61%, followed by bacterial pneumonia (15%), Gram-negative septicaemia (particularly non-typhoid Salmonella) (9%) and empyema (5%). Atypical pneumonias appeared to be rare. Most HIV-positive patients had CD4 counts indicative of advanced immunosuppression: 36% had CD4 counts below 100 x 10(6)/l, 19% between 100 and 199 x 10(6)/l, 29% between 200 and 499 x 10(6)/l, and 16% above 500 x 10(6)/l. Overall in-hospital mortality was 27% for HIV-positive patients and 22% for HIV-negative patients (P = 0.5). In a multivariate analysis, the strongest independent risk factors for death were cachexia (odds ratio [OR] 7.4, 95% confidence interval [CI] 2.1-26.3), male sex (OR 4.5, 95% CI 1.2-17.4) and age over 40 (OR 4.1, 95% CI 1.0-17.2). CONCLUSIONS: Tuberculosis and bacterial infections are the major causes of respiratory morbidity in immunosuppressed HIV-infected adults in this population. Efforts to improve the management of HIV-related disease need to focus on prevention and treatment of these infections. %G English %2 https://riip.hal.science/pasteur-00763560/document %2 https://riip.hal.science/pasteur-00763560/file/spectrum_dosso.pdf %L pasteur-00763560 %U https://riip.hal.science/pasteur-00763560 %~ RIIP %~ RIIP_COTEDIVOIRE