%0 Journal Article %T Dengue in Thailand and Cambodia: an assessment of the degree of underrecognized disease burden based on reported cases. %+ Pediatric Dengue Vaccine Initiative %+ Armed Forces Research Institute of Medical Sciences [Bangkok] (AFRIMS) %+ Institut Pasteur du Cambodge %+ Faculty of Tropical Medicine %+ Bureau of Epidemiology %+ National Dengue Control Program %A Wichmann, Ole %A Yoon, In-Kyu %A Vong, Sirenda %A Limkittikul, Kriengsak %A Gibbons, Robert V %A Mammen, Mammen P %A Ly, Sowath %A Buchy, Philippe %A Sirivichayakul, Chukiat %A Buathong, Rome %A Huy, Rekol %A Letson, G William %A Sabchareon, Arunee %Z The Pediatric Dengue Vaccine Initiative (PDVI) received funds from the Bill and Melinda Gates Foundation (grant number 23197). The Kamphaeng Phet study was supported by funds from the National Institutes of Health (grant number P01-AI034533) and the Military Infectious Diseases Research Program (MIDRP) (grant number S0016_04_AF), the Ratchaburi study was supported by funds from PDVI and the Thai Ministry of Public Health, and the Kampong Cham study received funds from PDVI and KOICA (Korea International Cooperation Agency). Except PDVI, the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. %< avec comité de lecture %@ 1935-2727 %J PLoS Neglected Tropical Diseases %I Public Library of Science %V 5 %N 3 %P e996 %8 2011 %D 2011 %R 10.1371/journal.pntd.0000996 %M 21468308 %K Adolescent %K Cambodia %K Child %K Preschool %K Cohort Studies %K Dengue %K Humans %K Incidence %K Infant %K Prospective Studies %K Thailand %Z Life Sciences [q-bio]/Microbiology and Parasitology/VirologyJournal articles %X BACKGROUND: Disease incidence data are needed to guide decision-making for public health interventions. Although dengue is a reportable disease in Thailand and Cambodia, the degree that reported incidence underrecognizes true disease burden is unknown. We utilized dengue incidence calculated from laboratory-confirmed outpatient and inpatient cases in prospective cohort studies to estimate the magnitude of dengue underrecognition and to establish more accurate disease burden estimates for these countries. METHODS AND FINDINGS: Cohort studies were conducted among children aged <15 years by members of a dengue field site consortium over at least 2 dengue seasons. Age-group specific multiplication factors (MFs) were computed by comparing data from three cohort studies to national surveillance data in the same province and year. In Thailand, 14,627 person-years of prospective cohort data were obtained in two provinces and 14,493 person-years from one province in Cambodia. Average annual incidence of laboratory-confirmed dengue was 23/1,000 and 25/1,000 in Thailand, and 41/1,000 in Cambodia. Calculated MFs in these provinces varied by age-group and year (range 0.4-29). Average age-group specific MFs were then applied to country-level reporting data and indicated that in Thailand a median 229,886 (range 210,612-331,236) dengue cases occurred annually during 2003-2007 and a median 111,178 (range 80,452-357,135) cases occurred in Cambodia in children <15 years of age. Average underrecognition of total and inpatient dengue cases was 8.7 and 2.6-fold in Thailand, and 9.1 and 1.4-fold in Cambodia, respectively. During the high-incidence year 2007, >95,000 children in Thailand and >58,000 children in Cambodia were estimated to be hospitalized due to dengue. CONCLUSION: Calculating MFs by comparing prospective cohort study data to locally-reported national surveillance data is one approach to more accurately assess disease burden. These data indicate that although dengue is regularly reported in many countries, national surveillance data significantly underrecognize the true burden of disease. %G English %Z Wichmann O %Z Yoon IK %Z Huy R %Z Letson GW %Z Sabchareon A. %Z Vong S %Z Limkittikul K %Z Gibbons RV %Z Mammen MP %Z Ly S %Z Buchy P %Z Sirivichayakul C %Z Buathong R %2 https://riip.hal.science/pasteur-00805501/document %2 https://riip.hal.science/pasteur-00805501/file/Dengue_in_Thailand_and_Cambodia_an_assessment_of_the_degree_of_underrecognized_disease_burden_based_on_reported_cases_W_Ole_2011_.pdf %L pasteur-00805501 %U https://riip.hal.science/pasteur-00805501 %~ RIIP %~ RIIP_CAMBODGE %~ PARTENARIATS-APP