%0 Journal Article %T Occupational exposure to silica and lung cancer: pooled analysis of two case-control studies in Montreal, Canada. %+ Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM) %+ McGill University = Université McGill [Montréal, Canada] %+ Institut Armand Frappier (INRS-IAF) %A Vida, Stephen %A Pintos, Javier %A Parent, Marie-Elise %A Lavoué, Jerome %A Siemiatycki, Jack %Z Funded by a number of agencies, including the National Cancer Institute of Canada, the Fonds de recherche en santé du Québec, the Canadian Institutes for Health Research, and the Guzzo-SRC Chair in Environment and Cancer. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. %< avec comité de lecture %@ 1055-9965 %J Cancer Epidemiology, Biomarkers and Prevention %I American Association for Cancer Research %V 19 %N 6 %P 1602-11 %8 2010-06 %D 2010 %R 10.1158/1055-9965.EPI-10-0015 %M 20501770 %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X BACKGROUND: Respirable crystalline silica is a highly prevalent occupational exposure and a recognized lung carcinogen. Most previous studies have focused on selected high-exposure occupational groups. This study examines the relationship between occupational exposure to silica and lung cancer in an occupationally diverse male population. METHODS: Two large population-based case-control studies of lung cancer were conducted in Montreal, one in 1979-1986 (857 cases, 533 population controls, 1,349 cancer controls) and the second in 1996-2001 (738 cases and 899 controls). Interviews provided descriptive lifetime job histories, smoking histories, and other information. Industrial hygienists translated job histories into histories of exposure to a host of occupational substances, including silica. Relative risk was estimated, adjusting for several potential confounders, including smoking. RESULTS: The odds ratio for substantial exposure to silica was 1.67 (95% confidence interval, 1.21-2.31) and for any exposure was 1.31 (95% confidence interval, 1.08-1.59). Joint effects between silica and smoking were between additive and multiplicative, perhaps closer to the latter. In this population, it is estimated that approximately 3% of lung cancers were attributable to substantial silica exposure. CONCLUSIONS: The carcinogenicity of inhaled crystalline silica was observed in a population with a wide variety of exposure circumstances. IMPACT: The finding of carcinogenicity across a wide range of occupations complements prior studies of specific high-exposure occupations. This suggests that the burden of cancer induced by silica may be much greater than previously thought. %G English %L pasteur-00819525 %U https://riip.hal.science/pasteur-00819525 %~ RIIP %~ INRS-IAF