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            <funder>We gratefully acknowledge technical assistance by R. Nera and A. Doyle and helpful comments from A. Rambaut and D. Falush. Support was provided by grants from the German Army Medical Corps (MSAB15A013) and the Science Foundation of Ireland (05/FE1/B882) to M.A., the National Key Program for Infectious Diseases of China (2008ZX10004-009) and the State Key Development Program for Basic Research of China (2009CB522600) to R.Y. and the US Department of Homeland Security (NBCH2070001; SHQDC-08-C00158) and US National Institutes of Health (AI065359) to P.K. and D.M.W. Whole genome sequencing of Y. pestis strains IP275, MG05-1020 and UG05-045 was supported by federal funds from the National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Department of Health and Human Services (N01 AI-30071), and sequencing of IP674 was supported by funding for Sanger Institute Pathogen Genomics by the Wellcome Trust. Genomic DNA of Y. pestis MG05-1020 was kindly provided by S. Bearden and M. Schriefer (Centers for Disease Control and Prevention, Fort Collins, Colorado, USA).</funder>
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                <idno type="eissn">1546-1718</idno>
                <title level="j">Nature Genetics</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">42</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">1140-3</biblScope>
                  <date type="datePub">2010-12</date>
                  <date type="dateEpub">2010-10-31</date>
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              <idno type="doi">10.1038/ng.705</idno>
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              <classCode scheme="mesh">Genetic Variation</classCode>
              <classCode scheme="mesh">Genome, Bacterial</classCode>
              <classCode scheme="mesh">Phylogeny</classCode>
              <classCode scheme="mesh">Plague</classCode>
              <classCode scheme="mesh">Polymorphism, Single Nucleotide</classCode>
              <classCode scheme="mesh">Sequence Analysis, DNA</classCode>
              <classCode scheme="mesh">Yersinia pestis</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
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              <p>Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs.</p>
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