%0 Journal Article %T Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones. %+ Department of Medicinal Chemistry and Technologies %+ Department of Biochemical Sciences "Rossi Fanelli" %A Valente, Sergio %A Tomassi, Stefano %A Tempera, Giampiero %A Saccoccio, Stefania %A Agostinelli, Enzo %A Mai, Antonello %< avec comité de lecture %@ 0022-2623 %J Journal of Medicinal Chemistry %I American Chemical Society %V 54 %N 23 %P 8228-32 %8 2011-12-08 %D 2011 %R 10.1021/jm201011x %M 22017497 %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X Monoamine oxidases (MAOs) are involved in various psychiatric and neurodegenerative disorders; hence, MAO inhibitors are useful agents in the therapy of Parkinson's disease, Alzheimer's dementia, and depression syndrome. Herein we report a novel series of 3-(1H-pyrrol-3-yl)-2-oxazolidinones 3-7 as reversible, highly potent and selective anti-MAO-A agents. In particular, 4b, 5b, and 4c showed a K(i-MAO-A) of 0.6, 0.8, and 1 nM, respectively, 4c being 200000-fold selective for MAO-A with respect to MAO-B. %G English %2 https://riip.hal.science/pasteur-00980200/document %2 https://riip.hal.science/pasteur-00980200/file/Valente2011.pdf %L pasteur-00980200 %U https://riip.hal.science/pasteur-00980200 %~ RIIP %~ RIIP_FCB