Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Year : 2013

Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.

Abstract

Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
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pasteur-01049065 , version 1 (25-07-2014)

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Tiziana Bozzini, Giorgia Botta, Michela Delfino, Silvano Onofri, Raffaele Saladino, et al.. Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.. Bioorganic and Medicinal Chemistry, 2013, 21 (24), pp.7699-708. ⟨10.1016/j.bmc.2013.10.026⟩. ⟨pasteur-01049065⟩

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