%0 Journal Article %T New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi. %+ Dipartimento di Chimica e Tecnologie del Farmaco %+ Department of Medicinal Chemistry and Technologies %+ Medical Parasitology and Infection Biology [Basel, Suisse] (MPI) %+ Dipartimento di Biotecnologie, Chimica e Farmacia %A Friggeri, Laura %A Scipione, Luigi %A Costi, Roberta %A Kaiser, Marcel %A Moraca, Francesca %A Zamperini, Claudio %A Botta, Bruno %A Di Santo, Roberto %A de Vita, Daniela %A Brun, Reto %A Tortorella, Silvano %Z This research was financially supported by grands from Sapienza, Università di Roma Progetti di Ricerca di Ateneo, and Ministero dell'istruzione, dell'Università e della Ricerca %< avec comité de lecture %@ 1948-5875 %J ACS Medicinal Chemistry Letters %I American Chemical Society %V 4 %N 6 %P 538-41 %8 2013-05-07 %D 2013 %R 10.1021/ml400039r %M 24900706 %K CYP51 %K Chagas disease %K Trypanosoma cruzi %K aminopyridine %K antiparasitic activity %K azole %Z Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology %Z Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologyJournal articles %X The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells. %G English %2 https://riip.hal.science/pasteur-01054197/document %2 https://riip.hal.science/pasteur-01054197/file/Friggeri_et_al.pdf %L pasteur-01054197 %U https://riip.hal.science/pasteur-01054197 %~ RIIP %~ RIIP_FCB