Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles BioMed Research International Year : 2014

Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis.

Ahmed-Riadh Rebai
  • Function : Author
  • PersonId : 768872
  • IdRef : 152768130

Abstract

Aims. Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations. Methods. We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.). Results. A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14-2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15-1.46, and P < 10(-3) and OR = 1.33, 95% CI = 1.13-1.56, and P = 0.001, resp.). Conclusion. Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.

Dates and versions

pasteur-01059829 , version 1 (02-09-2014)

Identifiers

Cite

Khaled Lasram, Nizar Ben Halim, Sana Hsouna, Rym Kefi, Imen Arfa, et al.. Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis.. BioMed Research International , 2014, 2014, pp.265274. ⟨10.1155/2014/265274⟩. ⟨pasteur-01059829⟩
97 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More