%0 Journal Article %T Therapeutic implications of immunogenic cell death in human cancer %+ Department of Internal Medicine and Medical Specialities %+ Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti %A Palombo, Fabio %A Focaccetti, Chiara %A Barnaba, Vincenzo %A Palombo, Fabio %A Barnaba, Vincenzo %< avec comité de lecture %@ 1664-3224 %J Frontiers in Immunology %I Frontiers %P 6 %8 2014-01-06 %D 2014 %R 10.3389/fimmu.2013.00503 %M 24432020 %K dendritic cells %K T cells %K chemotherapy %K immunogenic cell death %K tumor antigens %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers. %G English %2 https://riip.hal.science/pasteur-01148979/document %2 https://riip.hal.science/pasteur-01148979/file/fimmu-04-00503.pdf %L pasteur-01148979 %U https://riip.hal.science/pasteur-01148979 %~ RIIP %~ RIIP_FCB