%0 Journal Article %T Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients %+ Institut Pasteur de Tunis %+ Institut National de Nutrition et de Technologie Alimentaire (Tunis) (INNTA) %+ Engineering School of Statistics and Information Analysis ((LEGI-EPT-ESSAIT)) %+ Center of Biotechnology %+ Département de médecine préventive et de statistiques %+ Natl Ctr Blood Transfus-Tunis %+ National Center of Blood Transfusion %A Arfa, Imen %A Abid, Abdelmajid %A Nouira, Sonia %A Elloumi-Zghal, Houda %A Malouche, Dhafer %A Mannai, Imen %A Zorgati, Mohamed Majdi %A Ben Alaya, Nissaf %A Rebai, Ahmed-Riadh %A Zouari, Béchir %A Ben Ammar, Slim %A Ben Rayana, Mohamed Chiheb %A Hmida, Slama %A Blousa-Chabchoub, Samira %A Abdelhak, Sonia %Z This work was supported by the Tunisian Ministry for Scientific and Technological Research and Development of Competencies. %< avec comité de lecture %@ 1470-3203 %J Journal of the Renin-Angiotensin-Aldosterone System %I SAGE Publications (UK and US) %V 9 %N 1 %P 32 - 36 %8 2008-03 %D 2008 %R 10.3317/jraas.2008.002 %M 18404607 %K insertion-deletion polymorphism %K type 2 diabetes %K anglotensin-converting enzyme %K diabetic nephropathy %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Human health and pathology %Z Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismJournal articles %X Objective. The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. Design. A case-control study was conducted among 141 unrelated type 2 diabetic patients with (90 patients) or without nephropathy (51 patients) and 103 non-diabetic controls with normal fasting blood glucose. Genotyping was performed using a nested polymerase chain reaction amplification in order to identify correctly heterozygous individuals. Results. The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabetic patients with or without nephropathy (DD: 44%; ID: 46%; II: 10% vs. DD: 41%; ID: 47 %; II: 12%, respectively). There was also no significant statistical difference between the genotype distribution and allele frequencies of the (I/D) polymorphism in all type 2 diabetic subjects compared to non-diabetic controls with normal fasting blood glucose (DD: 43%; ID: 46%; II: 11% vs. DD: 37%; ID: 48%; II: 15%, respectively). Conclusions. In the present preliminary study, the (I/D) polymorphism within the ACE gene is likely not associated with diabetic nephropathy nor with type 2 diabetes in the Tunisian studied population. %G English %2 https://riip.hal.science/pasteur-01375209/document %2 https://riip.hal.science/pasteur-01375209/file/Lack%20of%20association.pdf %L pasteur-01375209 %U https://riip.hal.science/pasteur-01375209 %~ RIIP %~ RIIP_TUNIS