%0 Journal Article %T Reconstruction of Rift Valley fever transmission dynamics in Madagascar: estimation of force of infection from seroprevalence surveys using Bayesian modelling %+ Unité de Virologie [Antananarivo, Madagascar] (IPM) %+ Animal et gestion intégrée des risques (UPR AGIRs) %+ Institut Pasteur de Madagascar %+ Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) %+ Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA) %A Olive, Marie-Marie %A Grosbois, Vladimir %A Tran, Annelise %A Nomenjanahary, Lalaina, Arivony %A Rakotoarinoro, Mihaja %A Andriamandimby, Soa-Fy %A Rogier, Christophe %A Heraud, Jean-Michel %A Chevalier, Veronique %Z This study was supported by funds raised by (i) CIRAD (ii) the Centre National d’Etudes Spatiales (CNES; grant # 131163/00) (iii) the Institut Pasteur de Madagascar and Institut Pasteur International Network (Grant Dedonder Clayton). Cattle study of 2008 was supported in part by funds raised by the World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations (FAO) through the Central Emergency Response Fund of the United Nations. Cattle study of 2014 was funded by the Institut Pasteur of Madagascar (Internal Project). %< avec comité de lecture %@ 2045-2322 %J Scientific Reports %I Nature Publishing Group %V 7 %P 39870 %8 2017-01-04 %D 2017 %R 10.1038/srep39870 %M 28051125 %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Life Sciences [q-bio]/Microbiology and Parasitology/VirologyJournal articles %X The force of infection (FOI) is one of the key parameters describing the dynamics of transmission of vector-borne diseases. Following the occurrence of two major outbreaks of Rift Valley fever (RVF) in Madagascar in 1990–91 and 2008–09, recent studies suggest that the pattern of RVF virus (RVFV) transmission differed among the four main eco-regions (East, Highlands, North-West and South-West). Using Bayesian hierarchical models fitted to serological data from cattle of known age collected during two surveys (2008 and 2014), we estimated RVF FOI and described its variations over time and space in Madagascar. We show that the patterns of RVFV transmission strongly differed among the eco-regions. In the North-West and Highlands regions, these patterns were synchronous with a high intensity in mid-2007/mid-2008. In the East and South-West, the peaks of transmission were later, between mid-2008 and mid-2010. In the warm and humid northwestern eco-region favorable to mosquito populations, RVFV is probably transmitted all year-long at low-level during inter-epizootic period allowing its maintenance and being regularly introduced in the Highlands through ruminant trade. The RVF surveillance of animals of the northwestern region could be used as an early warning indicator of an increased risk of RVF outbreak in Madagascar. %G English %2 https://riip.hal.science/pasteur-01670563/document %2 https://riip.hal.science/pasteur-01670563/file/Reconstruction%20of%20Rift%20Valley%20Fever%20transmission%20dynamics.pdf %L pasteur-01670563 %U https://riip.hal.science/pasteur-01670563 %~ INSERM %~ IRD %~ CIRAD %~ RIIP %~ CNRS %~ UNIV-AMU %~ SANTE_PUB_INSERM %~ RIIP_MADAGASCAR %~ AGROPOLIS %~ AGREENIUM