Burden and Epidemiology of Influenza- and Respiratory Syncytial Virus-Associated Severe Acute Respiratory Illness Hospitalization in Madagascar, 2011-2016 - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Influenza and Other Respiratory Viruses Year : 2018

Burden and Epidemiology of Influenza- and Respiratory Syncytial Virus-Associated Severe Acute Respiratory Illness Hospitalization in Madagascar, 2011-2016

Abstract

Background Influenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza- and RSV-associated hospitalization are limited in Africa. Methods We conducted hospital-based surveillance for laboratory-confirmed influenza- and RSV-associated severe acute respiratory illness (SARI) among patients of any age at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011-2016. We estimated age-specific rates (per 100 000 population) of influenza- and RSV-associated SARI hospitalizations for the Antananarivo region and then extrapolated these rates to the national level. Results Overall, the mean annual national number of influenza-associated SARI hospitalizations for all age groups was 6609 (95% CI: 5381-7835-rate: 30.0; 95% CI: 24.4-35.6), 4468 (95% CI: 3796-5102-rate: 127.6; 95% CI: 108.4-145.7), 2141 (95% CI: 1585-2734-rate: 11.6; 95% CI: 8.6-14.8), and 339 (95% CI: 224-459-rate: 50.0; 95% CI: 36.3-74.4) among individuals aged <5, ≥5, and ≥65 years, respectively. For these same age groups, the mean annual number of RSV-associated SARI hospitalizations was 11 768 (95% CI: 10 553-12 997-rate: 53.4; 95% CI: 47.9-59.0), 11 299 (95% CI: 10 350-12 214-rate: 322.7; 95% CI: 295.6-348.8), 469 (95% CI: 203-783-rate: 2.5;95% CI: 1.1-4.2), and 36 (95% CI: 0-84-rate: 5.8; 0.0-13.5), respectively. Conclusion The burden of influenza- and RSV-associated SARI hospitalization was high among children aged <5 years. These first estimates for Madagascar will enable government to make informed evidence-based decisions when allocating scarce resources and planning intervention strategies to limit the impact and spread of these viruses
Fichier principal
Vignette du fichier
irv.12557.pdf (535.25 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-01798255 , version 1 (23-05-2018)
pasteur-01798255 , version 2 (18-06-2021)

Licence

Attribution

Identifiers

Cite

Joelinotahina H Rabarison, Stefano Tempia, Aina Harimanana, Julia Guillebaud, Norosoa Razanajatovo, et al.. Burden and Epidemiology of Influenza- and Respiratory Syncytial Virus-Associated Severe Acute Respiratory Illness Hospitalization in Madagascar, 2011-2016. Influenza and Other Respiratory Viruses, 2018, 13 (2), pp.138-147. ⟨10.1111/irv.12557⟩. ⟨pasteur-01798255v2⟩
181 View
244 Download

Altmetric

Share

Gmail Facebook X LinkedIn More