%0 Journal Article %T Solar insolation in springtime influences age of onset of bipolar I disorder %+ University Hospital Carl Gustav Carus [Dresden, Germany] %+ ChronoRecord Association Inc. [Fullerton, USA] %+ Dalhousie University [Halifax] %+ Soviet Psychoneurological Hospital [Urai, Russia] %+ Norwegian Centre for Mental Disorders Research [Oslo] (NORMENT) %+ University of Athens Medical School [Athens] %+ Università degli Studi di Cagliari = University of Cagliari (UniCa) %+ Faculty of Medicine [Hacettepe University] %+ Faculty of Medicine [Cologne] %+ National Institute of Mental Health and Neurosciences [Bangalore, Inde] (NIMHANS ) %+ Adelaide Medical School [Australia] %+ National Institute of Psychiatry Ramón de la Fuente Muñiz [Mexico City] (INPRF) %+ Variabilité de réponse aux Psychotropes (VariaPsy - U1144) %+ Ben-Gurion University of the Negev (BGU) %+ Deakin University [Burwood] %+ University of Melbourne %+ Hacettepe University = Hacettepe Üniversitesi %+ Butabika Hospital [Kampala, Uganda] %+ Università degli Studi di Siena = University of Siena (UNISI) %+ Mood Disorders Clinic, Dr. Jose Horwitz Psychiatric Institute, %+ Castle Peak Hospital [Hong Kong] %+ Centre for Innovation in Mental and Physical Health and Clinical Treatment [Geelong Victoria, Australia] (IMPACT) %+ Aristotle University of Thessaloniki %+ Mayo Clinic [Rochester] %+ University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU) %+ Northwestern University Feinberg School of Medicine %+ Mood Disorders Center of Ottawa (MDCO) %+ Kobe University %+ Tokyo Metropolitan Matsuzawa Hospital [Tokyo, Japan] %+ Institut Mondor de Recherche Biomédicale (IMRB) %+ Perception et Mémoire / Perception and Memory %+ National Institute for Health and Welfare [Helsinki] %+ Helsingin yliopisto = Helsingfors universitet = University of Helsinki %+ University of Tartu %+ Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS) %+ Institute of Neuroscience and Physiology [Göteborg] %+ Poznan University of Medical Sciences [Poland] (PUMS) %+ BIPOLAR Zentrum Wiener Neustadt [Wiener Neustadt, Austria] %+ Khanty-Mansiysk Clinical Psychoneurological Hospital [Khanty-Mansiysk, Russia] %+ Aarhus University Hospital %+ Universidade de São Paulo Medical School (FMUSP) %+ Karolinska Institutet [Stockholm] %+ Aalborg University [Denmark] (AAU) %+ Universidad de Antoquia %+ University of Calgary %+ University of Massachusetts Medical School [Worcester] (UMASS) %+ Institute of Mental Health [Singapore] %+ Michigan State University [Traverse City] %+ Department of Psychiatry [St. Olav's hospital, Trondheim] %+ Norwegian University of Science and Technology [Trondheim] (NTNU) %+ University of California [San Diego] (UC San Diego) %+ Asha Bipolar Clinic [Hyderabad, Telangana, India] (ABC) %+ Université de Tunis El Manar (UTM) %+ Faculté de Médecine de Tunis %+ Hospital Ángeles del Pedregal [Mexico City, Mexico] %+ Centro Lucio Bini [Cagliari, Italy] %+ Universidad Diego Portales [Santiago] (UDP) %+ Institute of Infectious Disease and Molecular Medicine (IDM) %+ Stanford University School of Medicine [CA, USA] %+ Goethe-Universität Frankfurt am Main %+ University of Missouri [Kansas City] (UMKC) %+ Universidade Federal da Bahia (UFBA) %+ University of Cape Town %+ Institute of Neuroscience Foundation Favaloro %+ Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie] %+ Tokyo Metropolitan Institute of Medical Science (TMIMS) %+ McLean Hospital [Belmont, Ma.] %+ University of Barcelona %+ Goethe-University Frankfurt am Main %+ Universitätsklinikum Frankfurt %+ Consejo Nacional de Ciencia y Tecnología [Mexico] (CONACYT) %+ Chapman University %+ Semel Institute for Neuroscience and Human Behavior [Los Angeles, Ca] %A Bauer, M. %A Glenn, T. %A Alda, M. %A Aleksandrovich, M. %A Andreassen, O. %A Angelopoulos, E. %A Ardau, R. %A Ayhan, Y. %A Baethge, C. %A Bharathram, R. %A Bauer, R. %A Baune, T. %A Becerra-Palars, C. %A Bellivier, F. %A Belmaker, R. %A Berk, M. %A Bersudsky, Y. %A Bicakci, Ş. %A Birabwa-Oketcho, H. %A Bjella, T. %A Bossini, L. %A Cabrera, J. %A Cheung, E. %A del Zompo, M. %A Dodd, S. %A Donix, M. %A Etain, B. %A Fagiolini, A. %A Fountoulakis, K. %A Frye, M. %A Gonzalez-Pinto, A. %A Gottlieb, F. %A Grof, P. %A Harima, H. %A Henry, C. %A Isometsä, T. %A Janno, S. %A Kapczinski, F. %A Kardell, M. %A Khaldi, S. %A Kliwicki, S. %A König, B. %A Kot, T. %A Krogh, R. %A Kunz, M. %A Lafer, B. %A Landén, M. %A Larsen, E. %A Lewitzka, U. %A Licht, R. %A Lopez-Jaramillo, C. %A Macqueen, G. %A Manchia, M. %A Marsh, W. %A Martinez-Cengotitabengoa, M. %A Melle, K. %A Meza-Urzúa, F. %A Yee Ming, M. %A Monteith, S. %A Morken, G. %A Mosca, E. %A Munoz, R. %A Mythri, S. %A Nacef, F. %A Nadella, R. %A Nery, F. %A Nielsen, E. %A O'Donovan, C. %A Omrani, A. %A Osher, Y. %A Østermark Sørensen, H. %A Ouali, U. %A Pica Ruiz, Y. %A Pilhatsch, M. %A Pinna, M. %A da Ponte, R. %A Quiroz, D. %A Ramesar, R. %A Rasgon, N. %A Reddy, M. %A Reif, A. %A Ritter, P. %A Rybakowski, J. %A Sagduyu, K. %A Scippa, M. %A Severus, E. %A Simhandl, C. %A Stein, J. %A Strejilevich, S. %A Subramaniam, M. %A Sulaiman, H. %A Suominen, K. %A Tagata, H. %A Tatebayashi, Y. %A Tondo, L. %A Torrent, C. %A Vaaler, E. %A Veeh, J. %A Vieta, E. %A Viswanath, B. %A Yoldi-Negrete, M. %A Zetin, M. %A Zgueb, Y. %A Whybrow, C. %Z Michael Berk is supported by an NHMRC Senior Principal Research Fellowship (1059660). Ole A Andreassen, Thomas DBjella and Ingrid Melle are supported by Research Council of Norway (223273) and KG Jebsen Stiftelsen. Ravi Nadella has received funding from the Accelerator program for Discovery in Brain disorders using Stem cells (ADBS), jointly funded by the Department of Biotechnology, Government of India, and the Pratiksha trust. Biju Viswanath has received funding by Department of Science and Technology INSPIRE scheme, Government of India. Mikael Landén was supported by grants from the Swedish Research Council (K2014‐62X‐14647‐12‐51 and K2010‐61P‐21568‐01‐4), the Swedish foundation for Strategic Research (KF10‐0039), and the Swedish Federal Government under the LUA/ALF agreement (ALF 20130032, ALFGBG‐142041). %< avec comité de lecture %@ 0001-690X %J Acta Psychiatrica Scandinavica %I Wiley %V 136 %N 6 %P 571-582 %8 2017-12 %D 2017 %R 10.1111/acps.12772 %M 28722128 %K circadian rhythm %K epidemiology %K solar insolation %K bipolar disorder %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density.RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001).CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge. %G English %Z We thank Haydeh Olofsson for valuable data management support. %L pasteur-01962050 %U https://riip.hal.science/pasteur-01962050 %~ INSERM %~ PASTEUR %~ UNIV-PARIS5 %~ UNIV-PARIS7 %~ RIIP %~ CNRS %~ SANTE_PUB_INSERM %~ LORIA2 %~ IMRB %~ UPEC %~ USPC %~ UNIV-PARIS %~ UP-SANTE %~ TEST3-HALCNRS %~ PER-MEM %~ PASTEUR_UMR3571 %~ CHAPMAN