%0 Journal Article %T Reduced Risk of Alcohol-Induced Pancreatitis With Cannabis Use %+ University of Massachusetts [Lowell] (UMass Lowell) %+ University of Massachusetts Medical School [Worcester] (UMASS) %+ North Shore Medical Center [Salem] (NCMC) %+ College of medicine %+ Institut Armand Frappier (INRS-IAF) %A Adejumo, Adeyinka Charles %A Akanbi, Olalekan %A Adejumo, Kelechi Lauretta %A Bukong, Terence Ndonyi %Z This work was funded by Start‐up funds to TNB from the IAF‐INRS, Canada %< avec comité de lecture %@ 0145-6008 %J Alcoholism: Clinical and Experimental Research %I Wiley %V 43 %N 2 %P 277-286 %8 2019-02 %D 2019 %R 10.1111/acer.13929 %M 30570765 %K Alcohol Abuse %K Cannabis %K Gallstones %K Incidence %K Pancreatitis %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X BACKGROUND: Pancreatitis is an increasingly common clinical condition that causes significant morbidity and mortality. Cannabis use causes conflicting effects on pancreatitis development. We conducted a larger and more detailed assessment of the impact of cannabis use on pancreatitis.METHODS: We analyzed data from 2012 to 2014 of the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample discharge records of patients 18 years and older. We used the International Classification of Disease, Ninth Edition codes, to identify 3 populations: those with gallstones (379,125); abusive alcohol drinkers (762,356); and non-alcohol-non-gallstones users (15,255,464). Each study population was matched for cannabis use record by age, race, and gender, to records without cannabis use. The estimation of the adjusted odds ratio (aOR) of having acute and chronic pancreatitis (AP and CP) made use of conditional logistic models.RESULTS: Concomitant cannabis and abusive alcohol use were associated with reduced incidence of AP and CP (aOR: 0.50 [0.48 to 0.53] and 0.77 [0.71 to 0.84]). Strikingly, for individuals with gallstones, additional cannabis use did not impact the incidence of AP or CP. Among non-alcohol-non-gallstones users, cannabis use was associated with increased incidence of CP, but not AP (1.28 [1.14 to 1.44] and 0.93 [0.86 to 1.01]).CONCLUSIONS: Our findings suggest a reduced incidence of only alcohol-associated pancreatitis with cannabis use. %G English %L pasteur-02133240 %U https://riip.hal.science/pasteur-02133240 %~ RIIP %~ INRS-IAF %~ TEST3-HALCNRS