<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of pasteur-03265221</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T08:44:21+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings</title>
            <author role="crp">
              <persName>
                <forename type="first">Olivia</forename>
                <surname>O'Connor</surname>
              </persName>
              <email type="md5">7bd597f4ca2d036700c2b441c023d288</email>
              <email type="domain">pasteur.nc</email>
              <idno type="idhal" notation="numeric">954675</idno>
              <idno type="halauthorid" notation="string">438591-954675</idno>
              <affiliation ref="#struct-260955"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tey Putita</forename>
                <surname>Ou</surname>
              </persName>
              <idno type="idhal" notation="numeric">807549</idno>
              <idno type="halauthorid" notation="string">2225329-807549</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8179-1382</idno>
              <affiliation ref="#struct-443468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <surname>Aubry</surname>
              </persName>
              <idno type="idhal" notation="numeric">1358418</idno>
              <idno type="halauthorid" notation="string">958827-1358418</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7733-7694</idno>
              <idno type="IDREF">https://www.idref.fr/188209824</idno>
              <affiliation ref="#struct-533510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphanie</forename>
                <surname>Dabo</surname>
              </persName>
              <email type="md5">6ad25231c68b4d0ad643d29de86a5b5a</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">stephanie-dabo</idno>
              <idno type="idhal" notation="numeric">746820</idno>
              <idno type="halauthorid" notation="string">8967-746820</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6275-0128</idno>
              <affiliation ref="#struct-533510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Russet</surname>
              </persName>
              <idno type="halauthorid">993975-0</idno>
              <affiliation ref="#struct-260955"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Girault</surname>
              </persName>
              <idno type="halauthorid">1158412-0</idno>
              <affiliation ref="#struct-260955"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Saraden</forename>
                <surname>In</surname>
              </persName>
              <idno type="halauthorid">1330812-0</idno>
              <affiliation ref="#struct-443468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marine</forename>
                <surname>Minier</surname>
              </persName>
              <idno type="idhal" notation="numeric">802598</idno>
              <idno type="halauthorid" notation="string">140556-802598</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8462-2584</idno>
              <affiliation ref="#struct-1072035"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thavry</forename>
                <surname>Hoem</surname>
              </persName>
              <idno type="halauthorid">1634054-0</idno>
              <affiliation ref="#struct-443468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Boyer</surname>
              </persName>
              <email type="md5">967c846e6301b7ad82caa1dde543c50b</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">sebastien-boyer</idno>
              <idno type="idhal" notation="numeric">745747</idno>
              <idno type="halauthorid" notation="string">42939-745747</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2946-586X</idno>
              <idno type="IDREF">https://www.idref.fr/223498629</idno>
              <idno type="IDREF">https://www.idref.fr/112136532</idno>
              <affiliation ref="#struct-1072036"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Dussart</surname>
              </persName>
              <email type="md5">a821e757368bcc06c6373eed4af9e8fc</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">philippe-dussart</idno>
              <idno type="idhal" notation="numeric">745623</idno>
              <idno type="halauthorid" notation="string">12475-745623</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1931-3037</idno>
              <idno type="IDREF">https://www.idref.fr/143356151</idno>
              <affiliation ref="#struct-443468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Pocquet</surname>
              </persName>
              <email type="md5">0d65883d8231251bdb669b6e472f5172</email>
              <email type="domain">pasteur.nc</email>
              <idno type="idhal" notation="string">nicolas-pocquet</idno>
              <idno type="idhal" notation="numeric">747975</idno>
              <idno type="halauthorid" notation="string">18620-747975</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3928-6803</idno>
              <affiliation ref="#struct-1072035"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Burtet-Sarramegna</surname>
              </persName>
              <email type="md5">69975158d3d1897c0e8dbb416b3034fc</email>
              <email type="domain">unc.nc</email>
              <idno type="idhal" notation="string">valerie-sarramegna</idno>
              <idno type="idhal" notation="numeric">736172</idno>
              <idno type="halauthorid" notation="string">26993-736172</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5293-5527</idno>
              <idno type="IDREF">https://www.idref.fr/25312722X</idno>
              <affiliation ref="#struct-529607"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Louis</forename>
                <forename type="middle">A</forename>
                <surname>Lambrechts</surname>
              </persName>
              <email type="md5">6ff82ed09edacc7bb837b8a73c0ddcb4</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">llambrechts</idno>
              <idno type="idhal" notation="numeric">172105</idno>
              <idno type="halauthorid" notation="string">38670-172105</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5958-2138</idno>
              <idno type="IDREF">https://www.idref.fr/111123798</idno>
              <affiliation ref="#struct-533510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Veasna</forename>
                <surname>Duong</surname>
              </persName>
              <idno type="idhal" notation="numeric">765625</idno>
              <idno type="halauthorid" notation="string">614961-765625</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0353-1678</idno>
              <affiliation ref="#struct-1072035"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Myrielle</forename>
                <surname>Dupont-Rouzeyrol</surname>
              </persName>
              <email type="md5">d95209cc59de62b4e9204b1753411e29</email>
              <email type="domain">pasteur.nc</email>
              <idno type="idhal" notation="string">mdupontr</idno>
              <idno type="idhal" notation="numeric">934089</idno>
              <idno type="halauthorid" notation="string">660881-934089</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6991-4893</idno>
              <affiliation ref="#struct-260955"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Philippe</forename>
                <surname>Dussart</surname>
              </persName>
              <email type="md5">a821e757368bcc06c6373eed4af9e8fc</email>
              <email type="domain">pasteur.fr</email>
            </editor>
            <funder ref="#projanr-24021"/>
            <funder ref="#projeurop-712234"/>
            <funder>This work was funded by the incentive grant, Inter-Pasteurian Concerted Actions (ACIP-06-2016). LL and FA were supported by the European Union’s Horizon 2020 research and innovation programme under ZikaPLAN grant agreement no. 734584 and the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-06-19 14:38:15</date>
              <date type="whenModified">2026-02-16 13:00:02</date>
              <date type="whenReleased">2021-06-21 14:28:35</date>
              <date type="whenProduced">2021-06-18</date>
              <date type="whenEndEmbargoed">2021-06-21</date>
              <ref type="file" target="https://riip.hal.science/pasteur-03265221v1/document">
                <date notBefore="2021-06-21"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://riip.hal.science/pasteur-03265221v1/file/Potential%20role%20of%20vector%20mediated%20natural%20selection%20in%20dengue%20virus%20genotype%20lineage%20replacements%20in%20two%20epidemiologically%20contrasted%20settings.pdf" id="file-3265221-2869918">
                <date notBefore="2021-06-21"/>
              </ref>
              <ref type="externalLink" target="https://www.tandfonline.com/doi/pdf/10.1080/22221751.2021.1944789?needAccess=true"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="166007">
                <persName>
                  <forename>Philippe</forename>
                  <surname>Dussart</surname>
                </persName>
                <email type="md5">a821e757368bcc06c6373eed4af9e8fc</email>
                <email type="domain">pasteur.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">pasteur-03265221</idno>
            <idno type="halUri">https://riip.hal.science/pasteur-03265221</idno>
            <idno type="halBibtex">oconnor:pasteur-03265221</idno>
            <idno type="halRefHtml">&lt;i&gt;Emerging microbes &amp; infections&lt;/i&gt;, 2021, 10 (1), pp.1346-1357. &lt;a target="_blank" href="https://dx.doi.org/10.1080/22221751.2021.1944789"&gt;&amp;#x27E8;10.1080/22221751.2021.1944789&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Emerging microbes &amp; infections, 2021, 10 (1), pp.1346-1357. &amp;#x27E8;10.1080/22221751.2021.1944789&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3265221-2869918"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-NC">Université de Nouvelle Calédonie</idno>
            <idno type="stamp" n="RIIP_CAMBODGE" corresp="RIIP">Institut Pasteur du Cambodge</idno>
            <idno type="stamp" n="RIIP_NOUVELLECALEDONIE" corresp="RIIP">Institut Pasteur de Nouvelle-Calédonie</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="UNC">Université de la Nouvelle-Calédonie</idno>
            <idno type="stamp" n="ISEA-UNC" corresp="UNC">ISEA - Institut de sciences exactes et appliquées</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="INTER-VIR-INSECT" corresp="PASTEUR">Interactions Virus-Insectes - Insect-Virus Interactions </idno>
            <idno type="stamp" n="PASTEUR_UMR2000" corresp="PASTEUR">Génomique évolutive, modélisation et santé - Institut Pasteur / CNRS UMR2000</idno>
            <idno type="stamp" n="TEST5-HALCNRS">collection test 5</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Olivia</forename>
                    <surname>O'Connor</surname>
                  </persName>
                  <email type="md5">7bd597f4ca2d036700c2b441c023d288</email>
                  <email type="domain">pasteur.nc</email>
                  <idno type="idhal" notation="numeric">954675</idno>
                  <idno type="halauthorid" notation="string">438591-954675</idno>
                  <affiliation ref="#struct-260955"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tey Putita</forename>
                    <surname>Ou</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">807549</idno>
                  <idno type="halauthorid" notation="string">2225329-807549</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8179-1382</idno>
                  <affiliation ref="#struct-443468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <surname>Aubry</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1358418</idno>
                  <idno type="halauthorid" notation="string">958827-1358418</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7733-7694</idno>
                  <idno type="IDREF">https://www.idref.fr/188209824</idno>
                  <affiliation ref="#struct-533510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphanie</forename>
                    <surname>Dabo</surname>
                  </persName>
                  <email type="md5">6ad25231c68b4d0ad643d29de86a5b5a</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">stephanie-dabo</idno>
                  <idno type="idhal" notation="numeric">746820</idno>
                  <idno type="halauthorid" notation="string">8967-746820</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6275-0128</idno>
                  <affiliation ref="#struct-533510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Russet</surname>
                  </persName>
                  <idno type="halauthorid">993975-0</idno>
                  <affiliation ref="#struct-260955"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Girault</surname>
                  </persName>
                  <idno type="halauthorid">1158412-0</idno>
                  <affiliation ref="#struct-260955"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Saraden</forename>
                    <surname>In</surname>
                  </persName>
                  <idno type="halauthorid">1330812-0</idno>
                  <affiliation ref="#struct-443468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marine</forename>
                    <surname>Minier</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">802598</idno>
                  <idno type="halauthorid" notation="string">140556-802598</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8462-2584</idno>
                  <affiliation ref="#struct-1072035"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thavry</forename>
                    <surname>Hoem</surname>
                  </persName>
                  <idno type="halauthorid">1634054-0</idno>
                  <affiliation ref="#struct-443468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Boyer</surname>
                  </persName>
                  <email type="md5">967c846e6301b7ad82caa1dde543c50b</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">sebastien-boyer</idno>
                  <idno type="idhal" notation="numeric">745747</idno>
                  <idno type="halauthorid" notation="string">42939-745747</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2946-586X</idno>
                  <idno type="IDREF">https://www.idref.fr/223498629</idno>
                  <idno type="IDREF">https://www.idref.fr/112136532</idno>
                  <affiliation ref="#struct-1072036"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Dussart</surname>
                  </persName>
                  <email type="md5">a821e757368bcc06c6373eed4af9e8fc</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">philippe-dussart</idno>
                  <idno type="idhal" notation="numeric">745623</idno>
                  <idno type="halauthorid" notation="string">12475-745623</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1931-3037</idno>
                  <idno type="IDREF">https://www.idref.fr/143356151</idno>
                  <affiliation ref="#struct-443468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Pocquet</surname>
                  </persName>
                  <email type="md5">0d65883d8231251bdb669b6e472f5172</email>
                  <email type="domain">pasteur.nc</email>
                  <idno type="idhal" notation="string">nicolas-pocquet</idno>
                  <idno type="idhal" notation="numeric">747975</idno>
                  <idno type="halauthorid" notation="string">18620-747975</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3928-6803</idno>
                  <affiliation ref="#struct-1072035"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Burtet-Sarramegna</surname>
                  </persName>
                  <email type="md5">69975158d3d1897c0e8dbb416b3034fc</email>
                  <email type="domain">unc.nc</email>
                  <idno type="idhal" notation="string">valerie-sarramegna</idno>
                  <idno type="idhal" notation="numeric">736172</idno>
                  <idno type="halauthorid" notation="string">26993-736172</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5293-5527</idno>
                  <idno type="IDREF">https://www.idref.fr/25312722X</idno>
                  <affiliation ref="#struct-529607"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Louis</forename>
                    <forename type="middle">A</forename>
                    <surname>Lambrechts</surname>
                  </persName>
                  <email type="md5">6ff82ed09edacc7bb837b8a73c0ddcb4</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">llambrechts</idno>
                  <idno type="idhal" notation="numeric">172105</idno>
                  <idno type="halauthorid" notation="string">38670-172105</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5958-2138</idno>
                  <idno type="IDREF">https://www.idref.fr/111123798</idno>
                  <affiliation ref="#struct-533510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Veasna</forename>
                    <surname>Duong</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">765625</idno>
                  <idno type="halauthorid" notation="string">614961-765625</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0353-1678</idno>
                  <affiliation ref="#struct-1072035"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Myrielle</forename>
                    <surname>Dupont-Rouzeyrol</surname>
                  </persName>
                  <email type="md5">d95209cc59de62b4e9204b1753411e29</email>
                  <email type="domain">pasteur.nc</email>
                  <idno type="idhal" notation="string">mdupontr</idno>
                  <idno type="idhal" notation="numeric">934089</idno>
                  <idno type="halauthorid" notation="string">660881-934089</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6991-4893</idno>
                  <affiliation ref="#struct-260955"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">104132</idno>
                <idno type="issn">2222-1751</idno>
                <idno type="eissn">2222-1751</idno>
                <title level="j">Emerging microbes &amp; infections</title>
                <imprint>
                  <publisher>Earliest : Springer-Nature ; Latest : Taylor &amp; Francis</publisher>
                  <biblScope unit="volume">10</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">1346-1357</biblScope>
                  <date type="datePub">2021-06-18</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1080/22221751.2021.1944789</idno>
              <idno type="pubmed">34139961</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">competition assay</term>
                <term xml:lang="en">transmission fitness</term>
                <term xml:lang="en">Aedes aegypti</term>
                <term xml:lang="en">genotype/lineage replacement</term>
                <term xml:lang="en">Dengue virus</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Dengue virus (DENV) evolutionary dynamics are characterized by frequent DENV genotype/lineage replacements, potentially associated with changes in disease severity and human immunity. New Caledonia (NC) and Cambodia, two contrasted epidemiological settings, respectively experienced a DENV-1 genotype IV to I replacement in 2012 and a DENV-1 genotype I lineage 3 to 4 replacement in 2005-2007, both followed by a massive dengue outbreak. However, their underlying evolutionary drivers have not been elucidated. Here, we tested the hypothesis that these genotype/lineage switches reflected a higher transmission fitness of the replacing DENV genotype/lineage in the mosquito vector using in vivo competition experiments. For this purpose, field-derived Aedes aegypti from NC and Cambodia were orally challenged with epidemiologically relevant pairs of four DENV-1 genotype I and IV strains from NC or four DENV-1 genotype I lineage 3 and 4 strains from Cambodia, respectively. The relative transmission fitness of each DENV-1 genotype/lineage was measured by quantitative RT-PCR for infection, dissemination, and transmission rates. Results showed a clear transmission fitness advantage of the replacing DENV-1 genotype I from NC within the vector. A similar but more subtle pattern was observed for the DENV-1 lineage 4 replacement in Cambodia. Our results support the hypothesis that vector-driven selection contributed to the DENV-1 genotype/lineage replacements in these two contrasted epidemiological settings, and reinforce the idea that natural selection taking place within the mosquito vector plays an important role in DENV short-term evolutionary dynamics.</p>
            </abstract>
            <particDesc>
              <org type="consortium">We gratefully thank the Clinical Research Department of the Center for Translational Research in Paris for its support in ethics procedures. We thank Laurent Wantiez and Katie Anders for their helpful discussion on statistical approaches. We also thank Louis Cognet for his contribution to samples handling.</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-260955" status="VALID">
          <idno type="RNSR">201324333X</idno>
          <orgName>Dengue et Arboviroses [Nouméa, Nouvelle-Calédonie]</orgName>
          <orgName type="acronym">URE-DA</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>Nouméa</addrLine>
              <country key="NC"/>
            </address>
            <ref type="url">https://www.institutpasteur.nc/presentation-ure-da/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-45419" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-443468" status="VALID">
          <orgName>Unité de Virologie / Virology Unit [Phnom Penh]</orgName>
          <desc>
            <address>
              <country key="KH"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-54022" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-533510" status="OLD">
          <idno type="RNSR">201923136V</idno>
          <orgName>Interactions Virus-Insectes - Insect-Virus Interactions</orgName>
          <orgName type="acronym">IVI</orgName>
          <date type="start">2019-01-01</date>
          <date type="end">2021-07-21</date>
          <desc>
            <address>
              <addrLine>Département Virologie25-28 rue du Docteur Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/insect-virus-interactions/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="UMR2000" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1072035" status="VALID">
          <idno type="RNSR">201324332W</idno>
          <orgName>Entomologie médicale [Nouméa, Nouvelle-Calédonie]</orgName>
          <orgName type="acronym">URE-EM</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>9-11 avenue Paul Doumer, 98800 Nouméa</addrLine>
              <country key="NC"/>
            </address>
            <ref type="url">http://www.institutpasteur.nc/presentation-ure-entomologie-medicale/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-45419" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1072036" status="VALID">
          <orgName>Medical and Veterinary Entomology - Entomologie médciale et vétérinaire [Phnom Penh, Cambodia]</orgName>
          <desc>
            <address>
              <addrLine>No. 5 Monivong Boulevard P.O Box. 983, Phnom Penh</addrLine>
              <country key="KH"/>
            </address>
            <ref type="url">https://www.pasteur-kh.org/medical-and-veterinary-entomology/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-54022" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-529607" status="VALID">
          <orgName>Institut des Sciences Exactes et Appliquées [Nouméa]</orgName>
          <orgName type="acronym">ISEA</orgName>
          <date type="start">2017-04-02</date>
          <desc>
            <address>
              <addrLine>Université de la Nouvelle-Calédonie, Campus de Nouville, 98851 Nouméa</addrLine>
              <country key="NC"/>
            </address>
            <ref type="url">https://isea.unc.nc/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300328" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-45419" status="VALID">
          <idno type="RNSR">195522890F</idno>
          <idno type="ROR">https://ror.org/04sqtjj61</idno>
          <orgName>Institut Pasteur de Nouvelle-Calédonie</orgName>
          <date type="start">1955-01-01</date>
          <desc>
            <address>
              <addrLine>B.P. 61 98845 Nouméa</addrLine>
              <country key="NC"/>
            </address>
            <ref type="url">http://www.institutpasteur.nc</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-54022" status="VALID">
          <idno type="ROR">https://ror.org/03ht2dx40</idno>
          <orgName>Institut Pasteur du Cambodge</orgName>
          <date type="start">1953-01-01</date>
          <desc>
            <address>
              <addrLine>BP 983 - 5 , Boulevard Monivong, Phnom Penh</addrLine>
              <country key="KH"/>
            </address>
            <ref type="url">http://www.pasteur-kh.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300328" status="VALID">
          <idno type="IdRef">060121076</idno>
          <idno type="ROR">https://ror.org/02jrgcx64</idno>
          <orgName>Université de la Nouvelle-Calédonie</orgName>
          <orgName type="acronym">UNC</orgName>
          <date type="start">1999-01-01</date>
          <desc>
            <address>
              <addrLine>Université de la Nouvelle-Calédonie, Campus de Nouville, BP R4 98851 Nouméa Cedex</addrLine>
              <country key="NC"/>
            </address>
            <ref type="url">https://unc.nc/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-24021" status="VALID">
          <idno type="anr">ANR-10-LABX-0062</idno>
          <orgName>IBEID</orgName>
          <desc>Integrative Biology of Emerging Infectious Diseases</desc>
          <date type="start">2010</date>
        </org>
        <org type="europeanProject" xml:id="projeurop-712234" status="VALID">
          <idno type="number">734584</idno>
          <idno type="program">H2020-SC1-2016-2017</idno>
          <idno type="call">H2020-SC1-2016-RTD-Zika</idno>
          <orgName>ZikaPLAN</orgName>
          <desc>Zika Preparedness Latin American Network</desc>
          <date type="start">2016-10-01</date>
          <date type="end">2021-03-31</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>