%0 Journal Article %T Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis %+ Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05) %+ Université de Carthage (Tunisie) (UCAR) %+ Laboratoire de Génétique Moléculaire Humaine %+ National Institute of Nutrition and Food Technology - Institut National « Zouhair Kallel » de Nutrition et de Technologie Alimentaire [Tunis] (INNTA) %+ Laboratoire central de biologie médicale, Institut Pasteur de Tunis %+ Université de Tunis El Manar (UTM) %A Dallali, Hamza %A Hechmi, Meriem %A Morjane, Imane %A Elouej, Sahar %A Jmel, Haifa %A Ben Halima, Yosra %A Abid, Abdelmajid %A Bahlous, Afef %A Barakat, Abdelhamid %A Jamoussi, Henda %A Abdelhak, Sonia %A Kefi, Rym %Z This work was supported by the E.C. Grant agreement no. 279171–1 for FP7 project MEDIGENE and by the Tunisian Ministry of Public Health and the Ministry of Higher Education and Scientific Research (LR11IPT05). %< avec comité de lecture %@ 1758-5996 %J Diabetology and Metabolic Syndrome %I BioMed Central %V 14 %N 1 %P 25 %8 2022-02-02 %D 2022 %R 10.1186/s13098-022-00794-0 %M 35109885 %K Hepatocyte Nuclear Factor-1-Alpha gene %K Metabolic disorders %K Lipids %K SNP %K Haplotype %K North Africa %Z Life Sciences [q-bio]Journal articles %X Background: Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and its components through an association study in the Tunisian population as well as by a meta-analysis. Methods: A total of 594 Tunisian individuals were genotyped for three variants (rs1169288, rs2464196 and rs735396) located in HNF1A gene using KASPar technology. Statistical analyses were performed with R software. The association was furthermore evaluated through a meta-analysis of our results with those obtained in a Moroccan population. Results: Our results showed no association between HNF1A variants and MetS in the Tunisian population. However, a significant association was observed between the variant rs735396 and a higher waist circumference. The stratified analysis according to the sex highlighted a significant association between the variant rs1169288 and high cholesterol levels only in women. Similarly, Haplotype analysis showed an association between the HNF1A minor haplotype and high total cholesterol mainly in women. Finally, our meta-analysis showed no association between HNF1A variants and MetS. Conclusions: Our findings exclude the involvement of the three HNF1A variants rs1169288, rs2464196 and rs735396 in the susceptibility to MetS in our studied Tunisian population but emphasize the role of these variants in the cholesterol homeostasis with sex-specific differences, which may serve to rise clinical consideration to early statin therapy in women carrying these genetic variants. %G English %2 https://riip.hal.science/pasteur-03561374/document %2 https://riip.hal.science/pasteur-03561374/file/mama12.pdf %L pasteur-03561374 %U https://riip.hal.science/pasteur-03561374 %~ RIIP %~ RIIP_TUNIS %~ RIIP_MAROC %~ OPENAIRE