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Journal Articles Nature Communications Year : 2021

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Tracey Goldstein


Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.
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Origin : Publication funded by an institution

Dates and versions

pasteur-03576361 , version 1 (16-02-2022)





Deborah Delaune, Vibol Hul, Erik A. Karlsson, Alexandre A. Hassanin, Tey Putita Ou, et al.. A novel SARS-CoV-2 related coronavirus in bats from Cambodia. Nature Communications, 2021, 12 (1), pp.6563. ⟨10.1038/s41467-021-26809-4⟩. ⟨pasteur-03576361⟩
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