%0 Journal Article %T Antigenic evolution of dengue viruses over 20 years %+ University of Florida [Gainesville] (UF) %+ National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH) %+ Armed Forces Research Institute of Medical Sciences [Bangkok] (AFRIMS) %+ Walter Reed Army Institute of Research %+ GlaxoSmithKline (GSK) %+ Institut Pasteur du Cambodge %+ University of Cambridge [UK] (CAM) %A Katzelnick, Leah, C. %A Coello Escoto, Ana %A Huang, Angkana, T. %A Garcia-Carreras, Bernardo %A Chowdhury, Nayeem %A Maljkovic Berry, Irina %A Chavez, Chris %A Buchy, Philippe %A Duong, Veasna %A Dussart, Philippe %A Gromowski, Gregory %A Macareo, Louis %A Thaisomboonsuk, Butsaya %A Fernandez, Stefan %A Smith, Derek, J. %A Jarman, Richard %A Whitehead, Stephen, S. %A Salje, Henrik %A Cummings, Derek, A. T. %Z This research was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (S.S.W. and L.C.K.), National Institute of Allergy and Infectious Diseases and National Institutes of Health Grant R01AI114703-01 (D.A.T.C., L.C.K., A.C.E., A.H., B.G.C., N.C., I.M.B., C.C., L.M., D.S., G.G., R.J., and H.S.), the Military Infectious Disease Research Program (A.H., I.M.B., L.M., G.G., and R.J.), and a European Research Council Grant 804744 (H.S.). Sequencing for infectious disease surveillance was additionally supported by the Global Emerging Infections Surveillance (GEIS) Branch (R.J.). The antigenic cartography toolkit was in part supported by NIAID-NIH Centers of Excellence for Influenza Research and Surveillance contract HHSN272201400008C (D.J.S.) for use on influenza virus. %< avec comité de lecture %@ 0036-8075 %J Science %I American Association for the Advancement of Science (AAAS) %V 374 %N 6570 %P 999-1004 %8 2021-11-18 %D 2021 %R 10.1126/science.abk0058 %M 34793238 %Z Life Sciences [q-bio]/Microbiology and Parasitology/Virology %Z Computer Science [cs]/Modeling and SimulationJournal articles %X Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcγ receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution. %G English %L pasteur-03576364 %U https://riip.hal.science/pasteur-03576364 %~ RIIP %~ RIIP_CAMBODGE %~ OPENAIRE %~ TDS-MACS