Metagenomics revealed a correlation of gut phageome with autism spectrum disorder - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Gut Pathogens Année : 2023

Metagenomics revealed a correlation of gut phageome with autism spectrum disorder

Résumé

The human gut bacteriome is believed to have pivotal influences on human health and disease while the particular roles associated with the gut phageome have not been fully characterized yet with few exceptions. It is argued that gut microbiota can have a potential role in autism spectrum disorders (ASD). The public microbiota database of ASD and typically developing (TD) Chinese individuals were analyzed for phage protein-coding units (pPCU) to find any link between the phageome and ASD. The gut phageome of ASD individuals showed a wider diversity and higher abundance compared to TD individuals. The ASD phageome was associated with a significant expansion of Caudoviricetes bacteriophages. Phages infecting Bacteroidaceae and prophages encoded within Faecalibacterium were more frequent in ASD than in TD individuals. The expansion and diversification of ASD phageome can influence the bacterial homeostasis by imposing pressure on the bacterial communities. In conclusion, the differences of phages community in in ASD and TD can be used as potential diagnosis biomarkers of ASD. Further investigations are needed to verify the role of gut phage communities in the pathogenesis of ASD.
Fichier principal
Vignette du fichier
s13099-023-00561-0.pdf (2.04 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

pasteur-04178004 , version 1 (07-08-2023)

Licence

Paternité

Identifiants

Citer

Khashayar Shahin, Abbas Soleimani-Delfan, Zihan He, Philippe Sansonetti, Jean-Marc Collard. Metagenomics revealed a correlation of gut phageome with autism spectrum disorder. Gut Pathogens, 2023, 15 (1), pp.39. ⟨10.1186/s13099-023-00561-0⟩. ⟨pasteur-04178004⟩

Collections

RIIP RIIP_SHANGHAI
76 Consultations
26 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More