Search - RIIP - Réseau International des Instituts Pasteur Access content directly

Filter your results

17 Results
authFullName_s : Sergio Valente
Image document

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Clemens Zwergel , Michael Schnekenburger , Federica Sarno , Cecilia Battistelli , Maria Cristina Manara , et al.
Clinical Epigenetics, 2019, 11 (1), pp.68. ⟨10.1186/s13148-019-0663-8⟩
Journal articles hal-02383678v1

Novel benzofuran-chromone and -coumarin derivatives: synthesis and biological activity in K562 human leukemia cells

Clemens Zwergel , Sergio Valente , Angela Salvato , Zhanjie Xu , Oualid Talhi , et al.
MedChemComm, 2013, 4 (12), pp.1571-1579. ⟨10.1039/c3md00241a⟩
Journal articles hal-01494094v1
Image document

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

Clemens Zwergel , Rossella Fioravanti , Giulia Stazi , Federica Sarno , Cecilia Battistelli , et al.
Cancers, 2020, 12 (2), pp.447. ⟨10.3390/cancers12020447⟩
Journal articles pasteur-03026533v1

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

Maria Cristina Manara , Sergio Valente , Camilla Cristalli , Giordano Nicoletti , Lorena Landuzzi , et al.
Molecular Cancer Therapeutics, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩
Journal articles hal-02383680v1
Image document

Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.

Sergio Valente , Stefano Tomassi , Giampiero Tempera , Stefania Saccoccio , Enzo Agostinelli , et al.
Journal of Medicinal Chemistry, 2011, 54 (23), pp.8228-32. ⟨10.1021/jm201011x⟩
Journal articles pasteur-00980200v1

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.

Simona Pilotto , Valentina Speranzini , Marcello Tortorici , Dominique Durand , Alexander Fish , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (9), pp.2752-7. ⟨10.1073/pnas.1419468112⟩
Journal articles hal-01448118v1

Identification of novel quinazoline derivatives as potent antiplasmodial agents

Anne Bouchut , Dante Rotili , Christine Pierrot , Sergio Valente , Sophia Lafitte , et al.
European Journal of Medicinal Chemistry, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩
Journal articles pasteur-03036828v1
Image document

Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.

Donghang Cheng , Sergio Valente , Sabrina Castellano , Gianluca Sbardella , Roberto Di Santo , et al.
Journal of Medicinal Chemistry, 2011, 54 (13), pp.4928-32. ⟨10.1021/jm200453n⟩
Journal articles pasteur-00968654v1

Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones in Diels-Alder Cycloaddition Reactions: Access to Coumarin-Based Polycycles with Cdc25 Phosphatase-Inhibiting Activity

Sergio Valente , Zhanjie Xu , Emilie Bana , Clemens Zwergel , Antonello Mai , et al.
European Journal of Organic Chemistry, 2013, 14, pp.2869-2877. ⟨10.1002/ejoc.201201736⟩
Journal articles istex hal-01494085v1
Image document

Combined HAT/EZH2 modulation leads to cancer-selective cell death

Francesca Petraglia , Abhishek Singh , Vincenzo Carafa , Angela Nebbioso , Mariarosaria Conte , et al.
Oncotarget, 2018, 9 (39), pp.25630-25646. ⟨10.18632/oncotarget.25428⟩
Journal articles hal-01873834v1
Image document

Specific activity of class II histone deacetylases in human breast cancer cells.

Vanessa Duong , Caroline Bret , Lucia Altucci , Antonello Mai , Céline Duraffourd , et al.
Molecular Cancer Research, 2008, 6 (12), pp.1908-19. ⟨10.1158/1541-7786.MCR-08-0299⟩
Journal articles inserm-00351047v1

Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines

Carole Seidel , Michael Schnekenburger , Clemens Zwergel , François Gaascht , Antonello Mai , et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (16), pp.3797 - 3801. ⟨10.1016/j.bmcl.2014.06.067⟩
Journal articles hal-01494600v1
Image document

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Alessandra Renzini , Nicoletta Marroncelli , Giorgia Cavioli , Silvia Di Francescantonio , Laura Forcina , et al.
Journal of Cachexia, Sarcopenia and Muscle, 2020, 11 (4), pp.929-946. ⟨10.1002/jcsm.12561⟩
Journal articles hal-03714907v1
Image document

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

Angela Nebbioso , Fabio Manzo , Marco Miceli , Mariarosaria Conte , Lucrezia Manente , et al.
EMBO Reports, 2009, 10 (7), pp.776-82. ⟨10.1038/embor.2009.88⟩
Journal articles inserm-00420167v1

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

Sergio Valente , Yiwei Liu , Michael Schnekenburger , Clemens Zwergel , Sandro Cosconati , et al.
Journal of Medicinal Chemistry, 2014, 57 (3), pp.701-713. ⟨10.1021/jm4012627⟩
Journal articles hal-01494552v1
Image document

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.

Sergio Valente , Ilaria Lepore , Carmela Dell'Aversana , Maria Tardugno , Sabrina Castellano , et al.
Biochimie, 2012, 94 (11), pp.2308-13. ⟨10.1016/j.biochi.2012.06.003⟩
Journal articles pasteur-00968696v1
Image document

New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

Christina Gros , Laurence Fleury , Virginie Nahoum , Céline Faux , Sergio Valente , et al.
Journal of Biological Chemistry, 2014, 290, pp.6293 - 6302. ⟨10.1074/jbc.m114.594671⟩
Journal articles hal-03002969v1