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The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function

Sophie Gobeil , Maximillian Ebert , Jaeok Park , Donald Gagné , Nicolas Doucet , et al.
Scientific Reports, 2019, 9 (1), pp.6656. ⟨10.1038/s41598-019-42866-8⟩
Journal articles pasteur-02275345v1

Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamase.

Nicolas Doucet , Pierre-Yves de Wals , Joelle N Pelletier
Journal of Biological Chemistry, 2004, 279 (44), pp.46295-303. ⟨10.1074/jbc.M407606200⟩
Journal articles pasteur-00736939v1
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Directed Evolution of Enzymes

Nicolas Doucet , Joelle N. Pelletier
Canadian Chemical News, 2004, 56 (4), pp.20-21
Journal articles pasteur-00736937v1
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Maintenance of native-like protein dynamics may not be required for engineering functional proteins

Sophie M.C. Gobeil , Christopher M. Clouthier , Jaeok Park , Donald Gagné , Albert M. Berghuis , et al.
Chemistry and Biology, 2014, 21 (10), pp.1330-1340. ⟨10.1016/j.chembiol.2014.07.016⟩
Journal articles hal-01196413v1

NMR investigation of Tyr105 mutants in TEM-1 beta-lactamase: dynamics are correlated with function.

Nicolas Doucet , Pierre-Yves Savard , Joelle N Pelletier , Stéphane M Gagné
Journal of Biological Chemistry, 2007, 282 (29), pp.21448-59. ⟨10.1074/jbc.M609777200⟩
Journal articles pasteur-00736958v1

Simulated annealing exploration of an active-site tyrosine in TEM-1 beta-lactamase suggests the existence of alternate conformations.

Nicolas Doucet , Joelle N Pelletier
Proteins - Structure, Function and Bioinformatics, 2007, 69 (2), pp.340-8. ⟨10.1002/prot.21485⟩
Journal articles istex pasteur-00736957v1