Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2008

Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.

Abstract

Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use.

Dates and versions

pasteur-00451015 , version 1 (27-01-2010)

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S. Page, F. Vernel-Pauillac, O. O'Connor, S. Bremont, F. Charavay, et al.. Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.. Antimicrobial Agents and Chemotherapy, 2008, 52 (11), pp.4155-8. ⟨10.1128/AAC.00082-08⟩. ⟨pasteur-00451015⟩
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