H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Journal of Virology Year : 2008

H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.

Abstract

Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.

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Virology
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Dates and versions

pasteur-00588964 , version 1 (27-04-2011)

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Joanna W Ho, Oren Hershkovitz, Malik Peiris, Alon Zilka, Ahuva Bar-Ilan, et al.. H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.. Journal of Virology, 2008, 82 (4), pp.2028-32. ⟨10.1128/JVI.02065-07⟩. ⟨pasteur-00588964⟩

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