FOXP3 and RORγt: transcriptional regulation of Treg and Th17.(Review) - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles International Immunopharmacology Year : 2011

FOXP3 and RORγt: transcriptional regulation of Treg and Th17.(Review)

Abstract

FOXP3(+)CD4(+)CD25(+) Regulatory T (Treg) cells and IL-17 producing helper T cells (Th17) are critical subsets of T cells which play essential roles in immune homeostasis. The Forkhead family transcription factor FOXP3 is predominantly expressed in Treg cells, where the FOXP3 ensemble is essential for Treg cell development and function. As FOXP3 is to Treg cells, the orphan retinoic acid nuclear receptor (ROR) family transcription factor RORγt is essential for Th17 development and function. In this review, we summarize recent progress of our understanding towards the molecular mechanisms underlying the differentiation and function of FOXP3(+) Treg cells and RORγt expressing Th17 cells. These may provide new insights into therapeutic intervention and targeting of human immune-deficient diseases.

Domains

Immunology
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

pasteur-00625175 , version 1 (21-09-2011)

Identifiers

Cite

Zuojia Chen, Fang Lin, Yayi Gao, Zhiyuan Li, Jing Zhang, et al.. FOXP3 and RORγt: transcriptional regulation of Treg and Th17.(Review). International Immunopharmacology, 2011, 11 (5), pp.536-42. ⟨10.1016/j.intimp.2010.11.008⟩. ⟨pasteur-00625175⟩

Collections

RIIP
104 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More