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Journal Articles Angewandte Chemie International Edition Year : 2012

A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?

Abstract

One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).

Domains

Virology

Dates and versions

pasteur-00664159 , version 1 (29-01-2012)

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Jimmy C. C. Lai, Jean-Michel Garcia, Jeffrey C. Dyason, Raphael Böhm, Paul D. Madge, et al.. A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?. Angewandte Chemie International Edition, 2012, epub ahead of print. ⟨10.1002/anie.201108245⟩. ⟨pasteur-00664159⟩

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