Exogenous VIP limits zymosan-induced generalized inflammation (ZIGI) in mice. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Immunology Letters Year : 2007

Exogenous VIP limits zymosan-induced generalized inflammation (ZIGI) in mice.

Abstract

Vasoactive intestinal peptide (VIP) was administered in a model of zymosan-induced generalized inflammation (ZIGI). Its beneficial action was associated with reduced TNF-alpha and increased IL-10 production, lowered levels of creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin in circulation. VIP diminished the level of RANTES and MIP-1alpha in peritoneal exudate and circulation. The neuropeptide inhibited NO release from stimulated peritoneal macrophages. Decreased spleen, liver and kidney enlargement and less pathological changes in liver were observed. The effect of VIP was attenuated by pretreatment with VIP antagonist (anti-VIP) before the induction of shock.

Domains

Immunology

Dates and versions

pasteur-00724513 , version 1 (21-08-2012)

Identifiers

Cite

Nina Ivanovska, Reni Kalfin, Maria Lazarova, Petya Dimitrova. Exogenous VIP limits zymosan-induced generalized inflammation (ZIGI) in mice.. Immunology Letters, 2007, 110 (2), pp.126-32. ⟨10.1016/j.imlet.2007.04.003⟩. ⟨pasteur-00724513⟩

Collections

RIIP RIIP_SA
38 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More