Annexin C4 in A. fumigatus: a proteomics approach to understand the function. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Journal of Proteomics Year : 2011

Annexin C4 in A. fumigatus: a proteomics approach to understand the function.

Abstract

Annexin C4 has been identified as a new member of fungal annexin family. In search of function, we have generated an annexin C4 disruptant strain of human pathogen, Aspergillus fumigatus. Detailed phenotypic analysis confirmed a non essential role of annexin C4 in the growth and sporulation of this pathogen. We applied a comparative proteomics strategy to understand the possible role of this protein in the fungus. The modification of respiratory chain proteins and stress response proteins suggests the occurrence of a mild oxidative stress in anxC4 disruptant strain. This may indicate a possible anti stress function of annexin C4 in A. fumigatus.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-00746501 , version 1 (29-10-2012)

Identifiers

Cite

Vahid Khalaj, Bahareh Azarian, Somayeh Enayati, Behrouz Vaziri. Annexin C4 in A. fumigatus: a proteomics approach to understand the function.. Journal of Proteomics, 2011, 74 (10), pp.1950-8. ⟨10.1016/j.jprot.2011.05.018⟩. ⟨pasteur-00746501⟩

Collections

RIIP RIIP_IRAN
31 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More