Oncolytic parvoviruses as cancer therapeutics. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Cytokine and Growth Factor Reviews Year : 2010

Oncolytic parvoviruses as cancer therapeutics.

Abstract

The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

pasteur-00748225 , version 1 (05-11-2012)

Identifiers

Cite

Jean Rommelaere, Karsten Geletneky, Assia L Angelova, Laurent Daeffler, Christiane Dinsart, et al.. Oncolytic parvoviruses as cancer therapeutics.. Cytokine and Growth Factor Reviews, 2010, 21 (2-3), pp.185-95. ⟨10.1016/j.cytogfr.2010.02.011⟩. ⟨pasteur-00748225⟩

Collections

RIIP RIIP_SA
123 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More