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Journal Articles Frontiers in Immunology Year : 2012

CD8(+) T cells in leishmania infections: friends or foes?

Abstract

Host protection against several intracellular pathogens requires the induction of CD8(+) T cell responses. CD8(+) T cells are potent effector cells that can produce high amounts of pro-inflammatory cytokines and kill infected target cells efficiently. However, a protective role for CD8(+) T cells during Leishmania infections is still controversial and largely depends on the infection model. In this review, we discuss the role of CD8(+) T cells during various types of Leishmania infections, following vaccination, and as potential immunotherapeutic targets.

Dates and versions

pasteur-00814922 , version 1 (17-04-2013)

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Simona Stäger, Sima Rafati. CD8(+) T cells in leishmania infections: friends or foes?. Frontiers in Immunology, 2012, 3, pp.5. ⟨10.3389/fimmu.2012.00005⟩. ⟨pasteur-00814922⟩
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