Structure of Penaeus stylirostris densovirus, a shrimp pathogen. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Journal of Virology Year : 2010

Structure of Penaeus stylirostris densovirus, a shrimp pathogen.

Abstract

Penaeus stylirostris densovirus (PstDNV), a pathogen of penaeid shrimp, causes significant damage to farmed and wild shrimp populations. In contrast to other parvoviruses, PstDNV probably has only one type of capsid protein that lacks the phospholipase A2 activity that has been implicated as a requirement during parvoviral host cell infection. The structure of recombinant virus-like particles, composed of 60 copies of the 37.5-kDa coat protein, the smallest parvoviral capsid protein reported thus far, was determined to 2.5-Å resolution by X-ray crystallography. The structure represents the first near-atomic resolution structure within the genus Brevidensovirus. The capsid protein has a β-barrel "jelly roll" motif similar to that found in many icosahedral viruses, including other parvoviruses. The N-terminal portion of the PstDNV coat protein adopts a "domain-swapped" conformation relative to its twofold-related neighbor similar to the insect parvovirus Galleria mellonella densovirus (GmDNV) but in stark contrast to vertebrate parvoviruses. However, most of the surface loops have little structural resemblance to any of the known parvoviral capsid proteins.

Dates and versions

pasteur-00819564 , version 1 (01-05-2013)

Identifiers

Cite

Bärbel Kaufmann, Valorie D Bowman, Yi Li, Jozsef Szelei, Peter J Waddell, et al.. Structure of Penaeus stylirostris densovirus, a shrimp pathogen.. Journal of Virology, 2010, 84 (21), pp.11289-96. ⟨10.1128/JVI.01240-10⟩. ⟨pasteur-00819564⟩

Collections

RIIP INRS-IAF
62 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More