The sweet side of tumor immunotherapy. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Immunotherapy Year : 2012

The sweet side of tumor immunotherapy.

Abstract

Carbohydrate signatures on tumor cells have functional implications in tumor growth and metastasis and constitute valuable tools in cancer diagnosis and immunotherapy. Increasing data regarding the mechanisms by which they are recognized by the immune system are facilitating the design of more efficient immunotherapeutic protocols based on cancer-associated glycan structures. Recent molecular and proteomic studies revealed that carbohydrates are recognized, not only by B cells and antibodies, but also by cells from the innate arm of immunity, as well as by T cells, and are able to induce specific T-cell immunity and cytotoxicity. In this review, we discuss and update the different strategies targeting tumor-associated carbohydrate antigens that are being evaluated for antitumor immunotherapy, an approach that will be highly relevant, especially when combined with other strategies, in the future fight against cancer.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

pasteur-00844603 , version 1 (15-07-2013)

Identifiers

Cite

Teresa Freire, Eduardo Osinaga. The sweet side of tumor immunotherapy.. Immunotherapy, 2012, 4 (7), pp.719-34. ⟨10.2217/imt.12.58⟩. ⟨pasteur-00844603⟩
34 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More