Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Current Opinion in Cell Biology Year : 2005

Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore.

Abstract

The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein complexes (mRNPs). Increasing evidence indicates that the protein complexes involved in distinct phases of manufacturing a bona fide mRNA in the nucleus are tightly coupled. Moreover, the recent demonstration that active genes migrate into preassembled, shared nuclear sub-compartments suggests that mRNAs are churned out in large 'transcription factories' with distinct but interconnected divisions. Nuclear factors have now been identified that specifically control the quality of mRNAs without affecting mRNP biogenesis or export.

Domains

Virology
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-00850262 , version 1 (06-08-2013)

Identifiers

Cite

Peter Sommer, Ulf Nehrbass. Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore.. Current Opinion in Cell Biology, 2005, 17 (3), pp.294-301. ⟨10.1016/j.ceb.2005.04.007⟩. ⟨pasteur-00850262⟩
76 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More