Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Clinical and Diagnostic Laboratory Immunology Year : 2004

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

Dates and versions

pasteur-00875161 , version 1 (21-10-2013)

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Meriem Ben-Ali, Mohamed-Ridha Barbouche, Soufia Bousnina, Abdellatif Chabbou, Koussay Dellagi. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.. Clinical and Diagnostic Laboratory Immunology, 2004, 11 (3), pp.625-6. ⟨10.1128/CDLI.11.3.625-626.2004⟩. ⟨pasteur-00875161⟩

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