mRNA stability and control of cell proliferation. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Biochemical Society Transactions Year : 2011

mRNA stability and control of cell proliferation.


Most of the studies on cell proliferation examine the control of gene expression by specific transcription factors that act on transcriptional initiation. In the last few years, it became evident that mRNA stability/turnover provides an important mechanism for post-transcriptional control of gene expression. In eukaryotes, mRNAs are mainly degraded after deadenylation by decapping and exosome pathways. Mechanisms of mRNA surveillance comprise deadenylation-independent pathways such as NMD (nonsense-mediated decay), when mRNAs harbour a PTC (premature termination codon), NSD (non-stop decay, when mRNAs lack a termination codon, and NGD (no-go decay), when mRNA translation elongation stalls. Many proteins involved in these processes are conserved from bacteria to yeast and humans. Recent papers showed the involvement of proteins deputed to decapping in controlling cell proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field.
Embargoed file
Embargoed file
Visibility date is undetermined

Dates and versions

pasteur-00975358 , version 1 (08-04-2014)



Cristina Mazzoni, Claudio Falcone. mRNA stability and control of cell proliferation.. Biochemical Society Transactions, 2011, 39 (5), pp.1461-5. ⟨10.1042/BST0391461⟩. ⟨pasteur-00975358⟩


13 View
0 Download



Gmail Mastodon Facebook X LinkedIn More