Polyamines: emerging players in bacteria-host interactions. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles International Journal of Medical Microbiology Year : 2013

Polyamines: emerging players in bacteria-host interactions.

Abstract

Polyamines are small polycationic molecules found in almost all cells and associated with a wide variety of physiological processes. In recent years it has become increasingly clear that, in addition to core physiological functions, polyamines play a crucial role in bacterial pathogenesis. Considerable evidence has built up that bacteria have evolved mechanisms to turn these molecules to their own advantage and a novel standpoint to look at host-bacterium interactions emerges from the interplay among polyamines, host cells and infecting bacteria. In this review, we highlight how human bacterial pathogens have developed their own resourceful strategies to exploit polyamines or manipulate polyamine-related processes to optimize their fitness within the host. Besides contributing to a better understanding of the complex relationship between a pathogen and its host, acquisitions in this field have a significant potential towards the development of novel antibacterial therapeutic approaches.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

pasteur-01044932 , version 1 (24-07-2014)

Identifiers

Cite

Maria Letizia Di Martino, Rosaria Campilongo, Mariassunta Casalino, Gioacchino Micheli, Bianca Colonna, et al.. Polyamines: emerging players in bacteria-host interactions.. International Journal of Medical Microbiology, 2013, 303 (8), pp.484-91. ⟨10.1016/j.ijmm.2013.06.008⟩. ⟨pasteur-01044932⟩

Collections

RIIP RIIP_FCB
25 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More