Hyaluronic acid nanohydrogels as a useful tool for BSAO immobilization in the treatment of melanoma cancer cells. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Macromolecular Bioscience Year : 2013

Hyaluronic acid nanohydrogels as a useful tool for BSAO immobilization in the treatment of melanoma cancer cells.

Abstract

An alternative anticancer therapy based on the use of bovine serum amine oxidase (BSAO), an enzyme that converts polyamines over-expressed in malignant cells, into hydrogen peroxide and aldehyde(s), thus inducing high cytotoxicity in cancer cells, was recently proposed. With the aim of improving the system efficacy by exploiting a nanotechnology approach, BSAO is covalently immobilized onto injectable nanohydrogels (NHs) based on cholesterol-graft-hyaluronic acid (HA-CH), a biocompatible conjugate that spontaneously leads to self-assembled structures in aqueous solutions. In this study, the physicochemical properties of the HA-CH-based NHs and the NHs cytocompatibility are reported. The properties of the NHs-BSAO system are also studied in terms of protein residual activity, both in vitro and on a model melanoma cell line.
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Dates and versions

pasteur-01053821 , version 1 (02-08-2014)

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Elita Montanari, Sabrina Capece, Chiara Di Meo, Martina Meringolo, Tommasina Coviello, et al.. Hyaluronic acid nanohydrogels as a useful tool for BSAO immobilization in the treatment of melanoma cancer cells.. Macromolecular Bioscience, 2013, 13 (9), pp.1185-94. ⟨10.1002/mabi.201300114⟩. ⟨pasteur-01053821⟩

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