Upregulation of TPX2 by STAT3: Identification of a Novel STAT3 Binding Site - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles PLoS ONE Year : 2014

Upregulation of TPX2 by STAT3: Identification of a Novel STAT3 Binding Site

Abstract

TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 59-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A specific STAT3 peptide inhibitor represses the expression of the Tpx2 gene and inhibits the binding of STAT3 to its consensus sequence in human cell lines where STAT3 is activated. These results indicate that activated STAT3 contributes to the over-expression of Tpx2 through the binding to an enhancer site.
Fichier principal
Vignette du fichier
pone.0113096.pdf (1.08 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-01148080 , version 1 (04-05-2015)

Licence

Attribution

Identifiers

Cite

Rossana Cocchiola, Caterina Grillo, Fabio Altieri, Silvia Chichiarelli, Carlo Turano, et al.. Upregulation of TPX2 by STAT3: Identification of a Novel STAT3 Binding Site. PLoS ONE, 2014, pp.7. ⟨10.1371/journal.pone.0113096⟩. ⟨pasteur-01148080⟩

Collections

RIIP RIIP_FCB
33 View
145 Download

Altmetric

Share

Gmail Facebook X LinkedIn More