Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Toxicon Year : 2012

Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.

Abstract

Envenomation by Hemiscorpius lepturus (H. lepturus) is associated with local necrosis, followed by systemic manifestations. In this work the LD₅₀ of H. lepturus venom were determined by subcutaneous (SC) injection in white Balb/c mice (5 mg/kg). Histopathological alterations in organs such as kidney, heart, liver, lungs, stomach and intestine were determined in 3, 6, 12 and 24 h following experimental (SC) envenoming injection of one LD ₅₀ of the venom in Balb/c mice. Histological studies showed degenerative changes in the kidney with disorganized glomeruli and necrotic tubular in 3 h and reached to its climax in 6 h. Myocardium showed massive myocytolysis with interstitial necrosis in 3 h and reached to its peak after 6 h past envenoming. Bowels showed edema of lamina propria and slight villous necrosis. The enzymatic activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in the serum in 9 h. No necrotic lesion observed in lungs and liver. The results indicate that the venom of H. lepturus is a highly cytotoxic, and induces massive tissue damages in specific organs, starting from the heart and kidney as the first target in 3 h and ends to the bowels in 6 h post envenomation.

Dates and versions

pasteur-01375142 , version 1 (02-10-2016)

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Mojgan Heidarpour, Emna Ennaifer, Hamed Ahari, Najet Srairi-Abid, Lamia Borchani, et al.. Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.. Toxicon, 2012, 59 (3), pp.373-8. ⟨10.1016/j.toxicon.2011.12.011⟩. ⟨pasteur-01375142⟩
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