Pyogenic bacterial infections in humans with MyD88 deficiency. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Science Year : 2008

Pyogenic bacterial infections in humans with MyD88 deficiency.

Manel Juan
  • Function : Author
Claudia Fortuny
  • Function : Author
J. Yague
  • Function : Author
J. Anton
  • Function : Author
Huey-Hsuan Chang
  • Function : Author
Ben-Zion Garty
  • Function : Author


MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections.

Dates and versions

pasteur-01375224 , version 1 (08-05-2017)



Horst von Bernuth, Capucine Picard, Zhongbo Jin, Rungnapa Pankla, Hui Xiao, et al.. Pyogenic bacterial infections in humans with MyD88 deficiency.. Science, 2008, 321 (5889), pp.691-6. ⟨10.1126/science.1158298⟩. ⟨pasteur-01375224⟩


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