Neopterin acts as an endogenous cognitive enhancer. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Brain, Behavior, and Immunity Year : 2016

Neopterin acts as an endogenous cognitive enhancer.


Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33mg/kg) in interleukin-10 knockout mice (IL-10(-/-)). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.

Dates and versions

pasteur-01498349 , version 1 (26-04-2017)



Karina Ghisoni, Aderbal S. Aguiar Jr, Paulo Alexandre de Oliveira, Filipe Carvalho Matheus, Laura Gabach, et al.. Neopterin acts as an endogenous cognitive enhancer.. Brain, Behavior, and Immunity, 2016, 56, pp.156-64. ⟨10.1016/j.bbi.2016.02.019⟩. ⟨pasteur-01498349⟩
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