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Journal Articles PLoS Medicine Year : 2016

Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982– 2012: A Systematic Analysis

1 CDC - Centers for Disease Control and Prevention [Atlanta]
2 University of Tampere [Finland]
3 University of Edinburgh
4 Public Health Foundation of India
5 Afghanistan National Public Health Institute
6 National Directorate of Public Health
7 Westmead Hospital [Sydney]
8 Institute of Epidemiology
9 Chinese Centre for Disease Control and Prevention
10 Caja Costarricense de Seguro Social
11 Institut Pasteur de Côte d'Ivoire
12 MINSAL - Ministerio de Salud de El Salvador
13 EPHI - Ethiopian Public Health Institute
14 University of Auckland [Auckland]
15 University of Otago [Dunedin, Nouvelle-Zélande]
16 University of Ghana
17 MSPAS - Ministerio de Salud Publica y Asistencia Social [Guatemala]
18 National Institute of Virology
19 National Institute of Health Research and Development
20 Centers for Disease Control and Prevention
21 Ministry of Health
22 IPM - Unité de Virologie [Antananarivo, Madagascar]
23 UASLP - Universidad Autonoma de San Luis Potosi [México]
24 National Centre for Public Health [Chisinau, Republic of Moldova]
25 National Influenza Center
26 Ministry of Health [Morocco]
27 Federal Ministry of Health
28 Ministerio de Salud Publica y Bienestar Social
29 Research Institute for Tropical Medicine
30 Ministry of Health
31 University of Pretoria [South Africa]
32 NICD - National Institute for Communicable Diseases [Johannesburg]
33 Ministry of Health
34 Ministry of Public Health
35 NIHE - National Institute of Hygiene and Epidemiology [Hanoi, Vietnam]
36 University Teaching Hospital
Mahmudur Rahman
Vida Mmbaga
  • Function : Author
Harry Campbell
  • Function : Author
  • PersonId : 892355

Abstract

BACKGROUND: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide. METHODS AND FINDINGS: We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5-17 y, and <18 y). We applied this proportion to global estimates of acute lower respiratory infection hospitalizations among children aged <1 y and <5 y, to obtain the number and per capita rate of influenza-associated hospitalizations by geographic region and socio-economic status. Influenza was associated with 10% (95% CI 8%-11%) of respiratory hospitalizations in children <18 y worldwide, ranging from 5% (95% CI 3%-7%) among children <6 mo to 16% (95% CI 14%-20%) among children 5-17 y. On average, we estimated that influenza results in approximately 374,000 (95% CI 264,000 to 539,000) hospitalizations in children <1 y-of which 228,000 (95% CI 150,000 to 344,000) occur in children <6 mo-and 870,000 (95% CI 610,000 to 1,237,000) hospitalizations in children <5 y annually. Influenza-associated hospitalization rates were more than three times higher in developing countries than in industrialized countries (150/100,000 children/year versus 48/100,000). However, differences in hospitalization practices between settings are an important limitation in interpreting these findings. CONCLUSIONS: Influenza is an important contributor to respiratory hospitalizations among young children worldwide. Increasing influenza vaccination coverage among young children and pregnant women could reduce this burden and protect infants <6 mo.
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pasteur-01675331 , version 1 (04-01-2018)

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CC0 - Public Domain Dedication

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Kathryn E Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente, Robert Booy, et al.. Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982– 2012: A Systematic Analysis. PLoS Medicine, 2016, 13 (3), pp.e1001977. ⟨10.1371/journal.pmed.1001977⟩. ⟨pasteur-01675331⟩
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