The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I) - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Antioxidants and Redox Signaling Year : 2017

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Wei Gao
  • Function : Author
Yang Wang
Long Yu
  • Function : Author
Andrey Novikov
  • Function : Author
Veridiana Virginio
  • Function : Author
Henrique Ferreira
  • Function : Author
Marisol Vieites
  • Function : Author
Vadim Gladyshev
  • Function : Author
Shaodong Dai
  • Function : Author

Abstract

New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus granulosus TGR, free and complexed with AuI-MPO, a novel gold inhibitor, together with inhibition assays were performed.

Dates and versions

pasteur-01882359 , version 1 (26-09-2018)

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Gustavo Salinas, Wei Gao, Yang Wang, Mariana Bonilla, Long Yu, et al.. The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxidants and Redox Signaling, 2017, 27 (18), pp.1491 - 1504. ⟨10.1089/ars.2016.6816⟩. ⟨pasteur-01882359⟩
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