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Journal Articles Infection and Immunity Year : 1999

Theileria annulata in CD5(+) macrophages and B1 B cells.

Abstract

Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5(+) clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5(+) B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5(+) B cells.

Dates and versions

pasteur-02024445 , version 1 (19-02-2019)

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Marie-Françoise Moreau, Jean-Laurent Thibaud, Leila Ben-Miled, Marie Chaussepied, Martin Baumgartner, et al.. Theileria annulata in CD5(+) macrophages and B1 B cells.. Infection and Immunity, 1999, 67 (12), pp.6678-6682. ⟨pasteur-02024445⟩
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