Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Journal of Infection in Developing Countries Year : 2009

Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal.


Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics. Methodology: H. pylori isolates from gastric biopsies from outpatients ≥ 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method. Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs ≥ 8 µg/l), whereas all isolates were susceptible to amoxicillin (MICs ≤ 0. 5 µg/ml) and ciprofloxacin (MICs ≤ 1µg/ml). Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.


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Dates and versions

pasteur-00584222 , version 1 (03-05-2011)





Abdoulaye Seck, Mouhamadou Mbengue, Amy Gassama-Sow, Lamine Diouf, Mouhamadou Mourtalla Ka, et al.. Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal.. Journal of Infection in Developing Countries, 2009, 3 (2), pp.137-140. ⟨10.3855/jidc.512⟩. ⟨pasteur-00584222⟩


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