Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles FEBS Letters Year : 2004

Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration.

Abstract

Retroviral infection triggers the cytoplasmic translocation of two Crm1-dependent shuttle factors, namely the Ini1 (integrase interactor 1, hSNF5) and the promyelocytic leukemia (PML) protein. Blocking nuclear export of shuttle factors by leptomycin B increases the efficiency of retroviral integration, suggesting that some may mediate antiviral activity. While PML was shown to counteract proviral establishment, it remained unclear whether Ini1, a protein implicated in various processes during human immunodeficiency virus replication, has the same potential. Employing RNA interference-mediated knock-down of Ini1, we show here that the simultaneous accumulation of both proteins in the cytoplasm likely reflects two non-interdependent phenomena. Furthermore, Ini1 does not interfere with retroviral integration, as cells lacking Ini1 show no increased infection susceptibility.

Domains

Virology
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-00850261 , version 1 (06-08-2013)

Identifiers

Cite

Annette Boese, Peter Sommer, Armelle Gaussin, Andreas Reimann, Ulf Nehrbass. Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration.. FEBS Letters, 2004, 578 (3), pp.291-6. ⟨10.1016/j.febslet.2004.11.016⟩. ⟨pasteur-00850261⟩

Collections

PASTEUR RIIP CNRS
104 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More